• Medientyp: E-Artikel
  • Titel: Highly Selective Apoptotic Cell Death Induced by Halo‐Salane Titanium Complexes
  • Beteiligte: Immel, Timo A.; Debiak, Malgorzata; Groth, Ulrich; Bürkle, Alexander; Huhn, Thomas
  • Erschienen: Wiley, 2009
  • Erschienen in: ChemMedChem, 4 (2009) 5, Seite 738-741
  • Sprache: Englisch
  • DOI: 10.1002/cmdc.200900038
  • ISSN: 1860-7179; 1860-7187
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  • Beschreibung: AbstractMetal‐based antitumor agents: Halogen‐substituted titanium salane complexes showed IC50 values comparable to cisplatin. In contrast to their alkyl‐substituted congeners, they almost exclusively induced apoptotic cell death. This unique combination of very low IC50 values and pronounced preference for apoptosis makes them promising therapeutic agents.magnified image