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Mattke, Matthias; Vogt, Kira; Bougatf, Nina; Welzel, Thomas; Oelmann‐Avendano, Jan; Hauswald, Henrik; Jensen, Alexandra; Ellerbrock, Malte; Jäkel, Oliver; Haberer, Thomas; Herfarth, Klaus; Debus, Jürgen; Uhl, Matthias

High control rates of proton‐ and carbon‐ion–beam treatment with intensity‐modulated active raster scanning in 101 patients with skull base chondrosarcoma at the Heidelberg Ion Beam Therapy Center

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  • Medientyp: E-Artikel
  • Titel: High control rates of proton‐ and carbon‐ion–beam treatment with intensity‐modulated active raster scanning in 101 patients with skull base chondrosarcoma at the Heidelberg Ion Beam Therapy Center
  • Beteiligte: Mattke, Matthias; Vogt, Kira; Bougatf, Nina; Welzel, Thomas; Oelmann‐Avendano, Jan; Hauswald, Henrik; Jensen, Alexandra; Ellerbrock, Malte; Jäkel, Oliver; Haberer, Thomas; Herfarth, Klaus; Debus, Jürgen; Uhl, Matthias
  • Erschienen: Wiley, 2018
  • Erschienen in: Cancer
  • Sprache: Englisch
  • DOI: 10.1002/cncr.31298
  • ISSN: 0008-543X; 1097-0142
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>BACKGROUND</jats:title><jats:p>The current study compares the results of irradiation with protons and irradiation with carbon ions via a raster scan technique in patients with G1 and G2 skull base chondrosarcomas.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>Between 2009 and 2014, a total of 101 patients (40 men and 61 women) with a median age of 44 years (range, 19‐77 years) were irradiated with carbon ions (79 patients) or protons (22 patients) via a raster scan technique at the Heidelberg Ion Beam Therapy Center. The median total dose was 60 Gy (relative biological effectiveness [RBE]) at 3 Gy per fraction for carbon ions and 70 Gy (RBE) at 2 Gy per fraction for protons. The median boost planning target volume was 38 cm<jats:sup>3</jats:sup> (range, 8‐133 cm<jats:sup>3</jats:sup>). Overall survival (OS) and local control (LC) were evaluated with the Kaplan‐Meier method.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>The median follow‐up period was 40 months (range, 0.8‐78.1 months). At the start of the irradiation, all patients had residual macroscopic tumors. Five patients (5%) developed a local recurrence during the follow‐up. The 1‐, 2‐, and 4‐year LC rates were 100%, 100%, and 100%, respectively, for protons and 98.6%, 97.2%, and 90.5%, respectively, for carbon ions. The OS rates during the same periods of time were 100%, 100%, and 100%, respectively, for protons and 100%, 98.5%, and 92.9%, respectively, for carbon ions. An age ≤ 44 years was associated with a trend for a better outcome. No toxicity worse than Common Toxicity Criteria grade 3 was observed after treatment.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>No significant difference between carbon ions and protons in the therapy of skull base chondrosarcoma could be detected in these initial retrospective results. <jats:bold><jats:italic>Cancer</jats:italic> 2018;124:2036‐44</jats:bold>. © <jats:italic>2018 American Cancer Society</jats:italic>.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang