Sinus histiocytosis with massive lymphadenopathy (rosai‐dorfman disease): Diagnosis with fine‐needle aspiration in a case with nodal and nasal involvement

Medientyp: E-Artikel

Titel: Sinus histiocytosis with massive lymphadenopathy (rosai‐dorfman disease): Diagnosis with fine‐needle aspiration in a case with nodal and nasal involvement

Beteiligte: Alegret, Ramiro Alvarez; Tello, Amelia Martinez; Ramirez, Teresa; Gállego, Paz; Martinez, David; Julián, Gregorio García

Erschienen: Wiley, 1995

Sprache: Englisch

DOI: 10.1002/dc.2840130413

ISSN: 1097-0339; 8755-1039

Schlagwörter: General Medicine ; Histology ; Pathology and Forensic Medicine

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Beschreibung: AbstractSinus histiocytosis with massive lymphadenopathy (SHML) is a rare entity characterized by the proliferation of cells belonging to the macrophage‐histiocyte family, but whose exact origin is unknown. A case of SHML occurring in a 62‐yr‐old female is described in which the diagnosis is initially suggested by fine‐needle aspiration (FNA) of a cervical node. The smears show a background of lymphocytes and plasma cells and large histiocytes with well‐preserved lymphocytes in their cytoplasm (emperipolesis or lymphophagocytosis). Both nodal and extranodal (nasal mass) involvement are confirmed by surgical biopsy. The immunohisto‐chemistry suggests that SHML cells are functionally activated macrophages. Eight months after diagnosis, the patient is clinically well, with partial improvement of lymphadenopathy. © 1995 Wiley‐Liss, Inc.

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