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Medientyp: E-Artikel Titel: Additional sex combs affects antennal development by means of spatially restricted repression of Antp and Wg Beteiligte: Halachmi, Naomi; Schulze, Karen L.; Inbal, Adi; Salzberg, Adi Erschienen: Wiley, 2007 Erschienen in: Developmental Dynamics, 236 (2007) 8, Seite 2118-2130 Sprache: Englisch DOI: 10.1002/dvdy.21239 ISSN: 1097-0177; 1058-8388 Schlagwörter: Developmental Biology Entstehung: Anmerkungen: Beschreibung: <jats:title>Abstract</jats:title><jats:p>Additional sex combs (Asx) is thought to function in protein complexes of both the Trithorax and Polycomb groups, but very little is known about its developmental roles. Here, we present a detailed analysis of Asx's role in antennal development. We show that loss of <jats:italic>Asx</jats:italic> in the antennal disc causes a complex phenotype, which consists of distal antenna‐to‐leg transformations and outgrowth of ectopic leg‐like appendages from the Dpp‐expressing domain of the disc. Our analyses suggest that these phenotypes are caused mainly by segment‐specific de‐repression of <jats:italic>Antp</jats:italic> and expansion of <jats:italic>wg</jats:italic> expression. We thus conclude that Asx functions normally to repress <jats:italic>Antp</jats:italic> and to restrict <jats:italic>wg</jats:italic> expression in specific regions of the developing disc. We also show that, in the absence of Asx's function, Antp expression does not lead to efficient repression of the antennal‐determining gene <jats:italic>hth</jats:italic>, suggesting that Asx is also required for the repression of <jats:italic>hth</jats:italic> by Antp. Developmental Dynamics 236:2118–2130, 2007. © 2007 Wiley‐Liss, Inc.</jats:p> Zugangsstatus: Freier Zugang