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Medientyp: E-Artikel Titel: Development of a Continuous‐Flow System for Catalysis with Palladium(0) Particles Beteiligte: Solodenko, Wladimir; Wen, Hongliang; Leue, Stefanie; Stuhlmann, Friedrich; Sourkouni‐Argirusi, Georgia; Jas, Gerhard; Schönfeld, Hagen; Kunz, Ulrich; Kirschning, Andreas Erschienen: Wiley, 2004 Erschienen in: European Journal of Organic Chemistry Sprache: Englisch DOI: 10.1002/ejoc.200400194 ISSN: 1434-193X; 1099-0690 Schlagwörter: Organic Chemistry ; Physical and Theoretical Chemistry Entstehung: Anmerkungen: Beschreibung: <jats:title>Abstract</jats:title><jats:p>Heterogeneous catalysis for organic synthesis under continuous‐flow conditions becomes possible by a new reactor‐based approach. Continuous‐flow reactors with a monolithic glass/polymer composite interior are loaded with palladium particles by ion exchange followed by reduction. When incorporated into a continuous‐flow setup (PASSflow) this reactor allows the transfer‐hydrogenation of alkenes, alkynes, nitro‐substituted aromatic compounds and benzyl ethers in the flow‐through mode. In addition, the activity of the catalysts is well suited to achieve Suzuki, Sonogashira and Heck cross‐coupling reactions in the absence of phosphanes or any other ligands, resulting in a greatly simplified purification. As an extension to this concept a bifunctional support was prepared inside the reactor consisting of Pd particles and an ion‐exchange group (hydroxide form). In the Suzuki− Miyaura reaction the reactor serves as a base for immobilisation and activation of the boronic acid as boronate and as a catalyst for promoting the C−C coupling reaction under continuous‐flow conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)</jats:p>