Beschreibung:
<jats:title>Abstract</jats:title><jats:p><jats:bold>The cover picture shows</jats:bold> the structure of closthioamide, the first example of secondary metabolites produced by anaerobic bacteria (see bottom, scanning‐electron micrograph of the natural producer <jats:italic>Clostridium cellulolyticum</jats:italic>). The natural product exhibits high antimicrobial activity, in particular against resistant pathogens (MRSA and VRE, see background). Because closthioamide represents a novel drug scaffold and its availability is limited by low production rates in <jats:italic>C. cellulolyticum</jats:italic> cultures, we developed a highly efficient total synthesis involving convergent peptide coupling and polythionation. Details are discussed in the Short Communication by C. Hertweck et al. on p. 1429 ff. We thank Dr. S. Nietzsche (Electron Microscopy Centre of the University Hospital, Jena) for providing scanning‐electron micrographs and Nico Ueberschaar for graphical processing.</jats:p>