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Medientyp:
E-Artikel
Titel:
Glucose as an Eco‐Friendly Reductant in a One‐Pot Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones
Beteiligte:
dos Santos, Thiago;
Grundke, Caroline;
Lucas, Tobias;
Großmann, Luca;
Clososki, Giuliano Cesar;
Opatz, Till
Erschienen:
Wiley, 2020
Erschienen in:
European Journal of Organic Chemistry, 2020 (2020) 41, Seite 6429-6432
Sprache:
Englisch
DOI:
10.1002/ejoc.202000970
ISSN:
1099-0690;
1434-193X
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one‐pot synthesis of 2,3‐dihydroquinazolin‐4(1<jats:italic>H</jats:italic>)‐ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco‐friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one‐pot sequences involving glucose as a reductant.</jats:p>