• Medientyp: E-Artikel
  • Titel: TiγA+δTCS1+ T cells in human thymus. Analysis of the T cell receptor
  • Beteiligte: Bosse, Roland; Heiken, Hans; Kolanus, Waldemar; Delany, Patricia; Schmidt, Reinhold E.; Triebel, Frederic
  • Erschienen: Wiley, 1992
  • Erschienen in: European Journal of Immunology, 22 (1992) 7, Seite 1947-1950
  • Sprache: Englisch
  • DOI: 10.1002/eji.1830220742
  • ISSN: 0014-2980; 1521-4141
  • Schlagwörter: Immunology ; Immunology and Allergy
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>TcR1<jats:sup>+</jats:sup> T cells in peripheral blood have been shown to express in an exclusive fashion either the TiγA or the δTCS1 epitope. Here, we characterize a subset of TcR1<jats:sup>+</jats:sup> T cells in fresh thymus co‐expressing the TiγA and δTCS1 epitopes. TcR1<jats:sup>dim</jats:sup> and TcR1<jats:sup>bright</jats:sup> clones can be distinguished. Biochemical and molecular studies on both types of clones generated from these thymocytes reveal a unique T cell receptor structure characterized by the use of a V<jats:sub>γ</jats:sub>9/C<jats:sub>γ</jats:sub>2‐encoded 55‐kDa γ chain nondisulfide linked to a V<jats:sub>δ</jats:sub>1‐encoded δ chain.</jats:p>