> Detailanzeige

Lithari, Chrysa; Moratti, Stephan; Weisz, Nathan

Thalamocortical interactions underlying visual fear conditioning in humans

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Thalamocortical interactions underlying visual fear conditioning in humans
  • Beteiligte: Lithari, Chrysa; Moratti, Stephan; Weisz, Nathan
  • Erschienen: Wiley, 2015
  • Erschienen in: Human Brain Mapping, 36 (2015) 11, Seite 4592-4603
  • Sprache: Englisch
  • DOI: 10.1002/hbm.22940
  • ISSN: 1065-9471; 1097-0193
  • Schlagwörter: Neurology (clinical) ; Neurology ; Radiology, Nuclear Medicine and imaging ; Radiological and Ultrasound Technology ; Anatomy
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Despite a strong focus on the role of the amygdala in fear conditioning, recent works point to a more distributed network supporting fear conditioning. We aimed to elucidate interactions between subcortical and cortical regions in fear conditioning in humans. To do this, we used two fearful faces as conditioned stimuli (CS) and an electrical stimulation at the left hand, paired with one of the CS, as unconditioned stimulus (US). The luminance of the CS was rhythmically modulated leading to “entrainment” of brain oscillations at a predefined modulation frequency. Steady‐state responses (SSR) were recorded by MEG. In addition to occipital regions, spectral analysis of SSR revealed increased power during fear conditioning particularly for thalamus and cerebellum contralateral to the upcoming US. Using thalamus and amygdala as seed‐regions, directed functional connectivity was calculated to capture the modulation of interactions that underlie fear conditioning. Importantly, this analysis showed that the thalamus drives the fusiform area during fear conditioning, while amygdala captures the more general effect of fearful faces perception. This study confirms ideas from the animal literature, and demonstrates for the first time the central role of the thalamus in fear conditioning in humans. <jats:italic>Hum Brain Mapp 36:4592–4603, 2015</jats:italic>. © <jats:bold>2015 Wiley Periodicals, Inc.</jats:bold></jats:p>
  • Zugangsstatus: Freier Zugang