> Detailanzeige

Zwicker, Felix; Roeder, Falk; Hauswald, Henrik; Thieke, Christian; Timke, Carmen; Schlegel, Wolfgang; Debus, Juergen; Münter, Marc W.; Huber, Peter E.

Reirradiation with intensity‐modulated radiotherapy in recurrent head and neck cancer

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Reirradiation with intensity‐modulated radiotherapy in recurrent head and neck cancer
  • Beteiligte: Zwicker, Felix; Roeder, Falk; Hauswald, Henrik; Thieke, Christian; Timke, Carmen; Schlegel, Wolfgang; Debus, Juergen; Münter, Marc W.; Huber, Peter E.
  • Erschienen: Wiley, 2011
  • Erschienen in: Head & Neck
  • Sprache: Englisch
  • DOI: 10.1002/hed.21663
  • ISSN: 1043-3074; 1097-0347
  • Schlagwörter: Otorhinolaryngology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>In this retrospective investigation we analyzed outcome and toxicity after intensity‐modulated reirradiation of recurrent head and neck cancer.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Thirty‐eight patients with local recurrent head and neck cancer were evaluated. The median dose of initial radiotherapy was 61 Gy. Reirradiation was carried out with step‐and‐shoot intensity‐modulated radiotherapy (median dose: 49 Gy).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Median overall survival was 17 months, and the 1‐ and 2‐year overall survival rates were 63% and 34%. The 1‐ and 2‐year local control rates were 57% and 53%. Distant spread occurred in 34%, and reirradiation induced considerable late toxicity in 21% of the patients. Thirty‐two percent showed increased xerostomia after reirradiation. The risk for xerostomia was significantly higher for cumulative mean doses of ≥45 Gy to parotid glands. Considering median cumulative maximum doses of 53 Gy to the spinal cord and 63 Gy to the brainstem, no late toxicities were observed.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Reirradiation with intensity‐modulated radiotherapy in recurrent head and neck cancer is feasible with acceptable toxicity and yields encouraging rates of local control and overall survival. © 2011 Wiley Periodicals, Inc. Head Neck, 2011</jats:p></jats:sec>