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Shiao, Jay C.; Mohamed, Abdallah S. R.; Messer, Jay A.; Hutcheson, Katherine A.; Johnson, Jason M.; Enderling, Heiko; Kamal, Mona; Warren, Benjamin W.; Pham, Brian; Morrison, William H.; Zafereo, Mark E.; Hessel, Amy C.; Lai, Stephen Y.; Kies, Merril S.; Ferrarotto, Renata; Garden, Adam S.; Schomer, Donald F.; Gunn, G. Brandon; Phan, Jack; Frank, Steven J.; Beadle, Beth M.; Weber, Randal S.; Lewin, Jan S.; Rosenthal, David I.;

Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx

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  • Medientyp: E-Artikel
  • Titel: Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx
  • Beteiligte: Shiao, Jay C.; Mohamed, Abdallah S. R.; Messer, Jay A.; Hutcheson, Katherine A.; Johnson, Jason M.; Enderling, Heiko; Kamal, Mona; Warren, Benjamin W.; Pham, Brian; Morrison, William H.; Zafereo, Mark E.; Hessel, Amy C.; Lai, Stephen Y.; Kies, Merril S.; Ferrarotto, Renata; Garden, Adam S.; Schomer, Donald F.; Gunn, G. Brandon; Phan, Jack; Frank, Steven J.; Beadle, Beth M.; Weber, Randal S.; Lewin, Jan S.; Rosenthal, David I.;
  • Erschienen: Wiley, 2017
  • Erschienen in: Head & Neck
  • Sprache: Englisch
  • DOI: 10.1002/hed.24804
  • ISSN: 1043-3074; 1097-0347
  • Schlagwörter: Otorhinolaryngology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The purpose of this study was to determine the impact of CT‐determined pretreatment primary tumor volume on survival and disease control in T4a laryngeal squamous cell carcinoma (SCC).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We retrospectively reviewed 124 patients with T4a laryngeal cancer from 2000‐2011. Tumor volume measurements were collected and correlated with outcomes.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Five‐year overall survival (OS) for patients with tumor volume ≥21 cm<jats:sup>3</jats:sup> treated with larynx preservation (n = 26 of 41) was significantly inferior compared to &lt;21 cm<jats:sup>3</jats:sup> (42% vs 64%, respectively; <jats:italic>P</jats:italic> = .003). Five‐year OS for patients with tumor volumes ≥21 cm<jats:sup>3</jats:sup> in the cohort treated with total laryngectomy followed by radiotherapy (RT; n = 42 of 83) was not statistically significant when compared to &lt;21 cm<jats:sup>3</jats:sup> (50% vs 63%, respectively; <jats:italic>P</jats:italic> = .058). On multivariate analysis, tumor volume ≥21 cm<jats:sup>3</jats:sup> was a significant independent correlate of worse disease‐specific survival (DSS; <jats:italic>P</jats:italic> = .004), event‐free survival (<jats:italic>P</jats:italic> = .005), recurrence‐free survival (RFS; <jats:italic>P</jats:italic> = .04), noncancer cause‐specific survival (<jats:italic>P</jats:italic> = .02), and OS (<jats:italic>P</jats:italic> = .0002).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Pretreatment CT‐based tumor volume is an independent prognostic factor of outcomes in T4a laryngeal cancer.</jats:p></jats:sec>