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Lüftner, Diana; Schuetz, Florian; Schneeweiss, Andreas; Hartkopf, Andreas; Bloch, Wilhelm; Decker, Thomas; Uleer, Christoph; Stötzer, Oliver; Foerster, Frank; Schmidt, Marcus; Mundhenke, Christoph; Tesch, Hans; Jackisch, Christian; Fischer, Thomas; Kreuzeder, Julia; Guderian, Gernot; Fasching, Peter A.

Efficacy and safety of everolimus plus exemestane in patients with hormone receptor‐positive, HER‐2‐negative advanced breast cancer: Results from the open‐label, multicentre, non‐interventional BRAWO study

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  • Medientyp: E-Artikel
  • Titel: Efficacy and safety of everolimus plus exemestane in patients with hormone receptor‐positive, HER‐2‐negative advanced breast cancer: Results from the open‐label, multicentre, non‐interventional BRAWO study
  • Beteiligte: Lüftner, Diana; Schuetz, Florian; Schneeweiss, Andreas; Hartkopf, Andreas; Bloch, Wilhelm; Decker, Thomas; Uleer, Christoph; Stötzer, Oliver; Foerster, Frank; Schmidt, Marcus; Mundhenke, Christoph; Tesch, Hans; Jackisch, Christian; Fischer, Thomas; Kreuzeder, Julia; Guderian, Gernot; Fasching, Peter A.
  • Erschienen: Wiley, 2024
  • Erschienen in: International Journal of Cancer, 155 (2024) 1, Seite 128-138
  • Sprache: Englisch
  • DOI: 10.1002/ijc.34912
  • ISSN: 0020-7136; 1097-0215
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: AbstractBRAWO, a real‐world study, assessed the efficacy, quality of life (QoL) and safety of EVE + EXE in postmenopausal women with HR+/HER2– advanced breast cancer (ABC) in routine clinical practice. Postmenopausal women with HR+/HER2‐ABC with recurrence or progression after a NSAI were included. Primary Observation parameters included the evaluation of the effectiveness of EVE + EXE. A multivariate‐analysis using Cox proportional hazard model was built to identify predictors of progression. Overall, 2100 patients were enrolled (August 2012–December 2017); 2074 were evaluable for efficacy and safety analyses. Majority of patients (60.6%) received EVE + EXE as first (28.7%) or second‐line (31.9%) therapy. Visceral metastases were present in 54.1% patients. Median progression‐free survival (mPFS) reported as 6.6 months (95%CI: 6.3–7.0). Multivariate‐analysis in a subset of patients (n = 1837) found higher body mass index (BMI) and non‐visceral metastases to be independent predictors of favorable PFS. Patients with a BMI of 20 to <25 had a mPFS of 6.0 (95%CI: 5.4–6.4) and those with a BMI ≥30 had mPFS of 8.5 (95%CI: 6.9–9.9). 41.2% patients achieved stable disease and 7.3% partial response. No major changes were observed QoL; 86.4% patients received stomatitis prophylaxis and 41.4% experienced EVE related AEs of stomatitis, mainly low grade. AEs occurred in 91.2% of patients, of which stomatitis (42.6%) and fatigue (19.8%) were most frequent. The BRAWO study provides real‐world evidence of efficacy and safety of EVE + EXE in patients with HR+, HER2− ABC. A high BMI and the absence of visceral metastases were independent predictors of PFS in this cohort of patients.