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Medientyp:
E-Artikel
Titel:
Systematic review and meta‐analysis of the performance of second‐trimester screening for prenatal detection of congenital heart defects
Beteiligte:
van Velzen, Christine L.;
Ket, Johannes C.F.;
van de Ven, Peter M.;
Blom, Nico A.;
Haak, Monique C.
Erschienen:
Wiley, 2018
Erschienen in:
International Journal of Gynecology & Obstetrics, 140 (2018) 2, Seite 137-145
Sprache:
Englisch
DOI:
10.1002/ijgo.12373
ISSN:
0020-7292;
1879-3479
Entstehung:
Anmerkungen:
Beschreibung:
AbstractBackgroundThe prenatal detection rate of congenital heart defects (CHDs) is increasing, but reported rates vary.ObjectivesTo determine the performance of the second‐trimester anomaly scan to detect CHD.Search strategyPubMed and Embase were searched for relevant studies in any language from inception to February 3, 2017. The search terms included “prenatal diagnosis” or “pregnancy,” “cardiovascular diseases” or “cardiac defects,” “congenital,” and “specificity,” or “sensitivity,” or “cohort study.”Selection criteriaCohort studies assessing the detection rate of CHD during population‐based prenatal screening from 1995 were eligible for inclusion.Data collection and analysisData were collected from identified studies; authors were approached for additional data when necessary. A review and meta‐analysis were performed. When possible, separate analyses were undertaken for isolated CHD cases.Main resultsMeta‐analysis of seven studies showed the pooled detection rate of CHD in unselected populations as 45.1% (95% confidence interval 33.5%–57.0%). However, the rate of detection of univentricular defects and heterotaxy was above 85%. Similar rates were found among cases of isolated CHD.ConclusionsPrenatal detection showed a strong correlation with CHD severity. The detection of conotruncal anomalies needs to improve. A thoroughly organized screening program will be essential to achieve a higher detection rate.