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Medientyp: E-Artikel Titel: Vitamin E: Regulatory role of metabolites Beteiligte: Birringer, Marc; Lorkowski, Stefan Erschienen: Wiley, 2019 Erschienen in: IUBMB Life, 71 (2019) 4, Seite 479-486 Sprache: Englisch DOI: 10.1002/iub.1988 ISSN: 1521-6543; 1521-6551 Entstehung: Anmerkungen: Beschreibung: AbstractVitamin E plays an important role as a lipophilic antioxidant in cellular redox homeostasis. Besides this function, numerous non‐antioxidant properties of this vitamin have been discovered in the past. DNA microarray technology revealed a complex regulatory network influenced by the different vitamin E forms (Rimbach et al., Molecules, 15, 1746 (2010); Galli et al., Free Radic. Biol. Med., 102, 16 (2017)); however, little is known about the biological activity of vitamin E metabolites. A new chapter of vitamin E research was been opened when endogenous long‐chain tocopherol metabolites were identified and their high biological activity in vitro and in vivo was recognized (Schmölz et al., World J. Biol. Chem., 7, 14 (2016); Torquato et al., J. Pharm. Biomed. Anal., 124, 399 (2016)). Just recently, it was shown that an endogenous metabolite of vitamin E inhibits 5‐lipoxygenase at nanomolar concentrations, thereby limiting inflammation (Pein et al., Nat. Commun., 9, 3834 (2018)). Furthermore, long‐chain vitamin E metabolites (LCM) exhibit hormone‐like activities similar to the lipid soluble vitamins A and D (Galli et al., Free Radic. Biol. Med., 102, 16 (2017); Schubert et al., Antioxidants, 7 (2018)). This review aims at summarizing recent findings on the regulatory activities of vitamin E metabolites, especially of LCMs. © 2018 IUBMB Life, 71(4):479–486, 2019 Zugangsstatus: Freier Zugang