• Medientyp: E-Artikel
  • Titel: Screening by Anti‐Endomysium Antibody for Celiac Disease in Diabetic Children and Adolescents in Austria
  • Beteiligte: Schober, Edith; Bittmann, Barbara; Granditsch, Gerhard; Huber, Wolf‐Dietrich; Hüppe, Amelie; Jäger, Andrea; Oberhuber, Georg; Rami, Birgit; Reichel, Gerlinde
  • Erschienen: Wiley, 2000
  • Erschienen in: Journal of Pediatric Gastroenterology and Nutrition, 30 (2000) 4, Seite 391-396
  • Sprache: Englisch
  • DOI: 10.1002/j.1536-4801.2000.tb02758.x
  • ISSN: 0277-2116; 1536-4801
  • Schlagwörter: Gastroenterology ; Pediatrics, Perinatology and Child Health
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  • Beschreibung: ABSTRACTBackground:Unrecognized celiac disease (CD) may be found in a substantial proportion of patients with type 1 diabetes mellitus.Methods:A cohort of 403 Austrian children and adolescents with type 1 diabetes mellitus (210 males and 193 females; age range, 1–22 years) was screened for celiac disease using the IgA anti‐endomysium antibody test (EMA) and the immunoglobulin (Ig)G anti‐gliadin (AGA‐IgG) and IgA anti‐gliadin (AGA‐IgA) antibody test.Results:Twelve patients' sera (2.98%) yielded positive EMA results and two patients' sera (0.49%) with IgA deficiency had high AGA‐IgG values. All but one of these patients underwent intestinal biopsy. Six (1.49%) had clear histologic evidence of CD (flat mucosa), whereas three (0.74%) showed minor histologic changes (increase in intraepithelial lymphocytes) and four (0.99%), including the EMA‐negative patients with IgA deficiency, had a normal mucosa. When the cases with silent and potential CD were combined, the overall prevalence in the current cohort was 2.98%. There was no difference in the hemoglobin (Hb)A1c level between antibody‐positive and ‐negative patients, and subsequent gluten‐free diet did not change this metabolic parameter.Conclusion:The prevalence of clinically unrecognized CD, found by EMA screening, is much higher in Austrian children with diabetes than in a comparable population without diabetes. The prevalence of CD in diabetic children in Austria is distinctly lower, however, than in several other countries.
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