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Medientyp:
E-Artikel
Titel:
Rat sinus mucosa‐ and periosteum‐derived exosomes accelerate osteogenesis
Beteiligte:
Sun, Ruinan;
Xu, Shuyu;
Wang, Zuolin
Erschienen:
Wiley, 2019
Erschienen in:
Journal of Cellular Physiology, 234 (2019) 12, Seite 21947-21961
Sprache:
Englisch
DOI:
10.1002/jcp.28758
ISSN:
0021-9541;
1097-4652
Entstehung:
Anmerkungen:
Beschreibung:
AbstractGuided bone regeneration (GBR) is commonly used for alveolar bone augmentation. The paracrine mechanism in the field of bone tissue engineering has been emphasized in recent years and exosomes are considered to have the potential of promoting osteogenesis. We aimed to study the influence of sinus mucosa and periosteum on bone regeneration through paracrine stimulation, especially via exosomes, and compare the differences between them. Here, we report that conditioned medium (CM) from sinus mucosa‐derived cells (SMCs) and periosteum‐derived cells (PCs) and the isolated exosomes enhanced the proliferation, migration and osteogenic differentiation of bone marrow–derived mesenchymal stem cells (BM‐MSCs) in vitro. A rat model of femoral bone defects was used to demonstrate that the exosomes derived from SMCs (SMC‐Exos) and PCs (PC‐Exos) can accelerate bone formation in vivo. Furthermore, we present a preliminary discussion of the possible functional components involved in the effects of SMC‐Exos and PC‐Exos on bone regeneration. In conclusion, these results demonstrated that the sinus mucosa and periosteum can accelerate osteogenesis through paracrine effects and the exosomes play important roles in this process.