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Lam, Christopher X. F.; Hutmacher, Dietmar W.; Schantz, Jan‐Thorsten; Woodruff, Maria Ann; Teoh, Swee Hin

Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo

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  • Medientyp: E-Artikel
  • Titel: Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo
  • Beteiligte: Lam, Christopher X. F.; Hutmacher, Dietmar W.; Schantz, Jan‐Thorsten; Woodruff, Maria Ann; Teoh, Swee Hin
  • Erschienen: Wiley, 2009
  • Erschienen in: Journal of Biomedical Materials Research Part A, 90A (2009) 3, Seite 906-919
  • Sprache: Englisch
  • DOI: 10.1002/jbm.a.32052
  • ISSN: 1549-3296; 1552-4965
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The use of polycaprolactone (PCL) as a biomaterial, especially in the fields of drug delivery and tissue engineering, has enjoyed significant growth. Understanding how such a device or scaffold eventually degrades <jats:italic>in vivo</jats:italic> is paramount as the defect site regenerates and remodels. Degradation studies of three‐dimensional PCL and PCL‐based composite scaffolds were conducted <jats:italic>invitro</jats:italic> (in phosphate buffered saline) and <jats:italic>in vivo</jats:italic> (rabbit model). Results up to 6 months are reported. All samples recorded virtually no molecular weight changes after 6 months, with a maximum mass loss of only about 7% from the PCL‐composite scaffolds degraded <jats:italic>in vivo</jats:italic>, and a minimum of 1% from PCL scaffolds. Overall, crystallinity increased slightly because of the effects of polymer recrystallization. This was also a contributory factor for the observed stiffness increment in some of the samples, while only the PCL‐composite scaffold registered a decrease. Histological examination of the <jats:italic>in vivo</jats:italic> samples revealed good biocompatibility, with no adverse host tissue reactions up to 6 months. Preliminary results of medical‐grade PCL scaffolds, which were implanted for 2 years in a critical‐sized rabbit calvarial defect site, are also reported here and support our scaffold design goal for gradual and late molecular weight decreases combined with excellent long‐term biocompatibility and bone regeneration. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</jats:p>