Plasmonic nanoprobes for SERS biosensing and bioimaging

Medientyp: E-Artikel
Titel: Plasmonic nanoprobes for SERS biosensing and bioimaging
Beteiligte: Vo‐Dinh, Tuan; Wang, Hsin‐Neng; Scaffidi, Jonathan
Erschienen: Wiley, 2010
Erschienen in: Journal of Biophotonics
Sprache: Englisch
DOI: 10.1002/jbio.200910015
ISSN: 1864-063X; 1864-0648
Schlagwörter: General Physics and Astronomy ; General Engineering ; General Biochemistry, Genetics and Molecular Biology ; General Materials Science ; General Chemistry
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>This article provides an overview of the development and application of plasmonic nanoprobes developed in our laboratory for biosensing and bioimaging. We describe the use of plasmonics surface‐enhanced Raman scattering (SERS) gene probes for the detection of diseases using DNA hybridization to target biospecies (HIV gene, breast cancer genes etc.). For molecular imaging, we describe a hyperspectral surface‐enhanced Raman imaging (HSERI) system that combines imaging capabilities with SERS detection to identify cellular components using Raman dye‐labeled silver nanoparticles in cellular systems The detection of specific target DNA sequences associated with breast cancer using “molecular sentinel” nanoprobes and the use of a plasmonic nanosensor to monitor pH in single cells are presented and discussed. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)</jats:p>

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