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Medientyp: E-Artikel Titel: Enveloping bioabsorbable polyglycolide membrane and immobilization in achilles tendon repair: A comparative experimental study on rabbits Beteiligte: Pihlajamäki, Harri; Tynninen, Olli; Karjalainen, Pertti; Rokkanen, Pentti Erschienen: Wiley, 2008 Erschienen in: Journal of Orthopaedic Research Sprache: Englisch DOI: 10.1002/jor.20504 ISSN: 0736-0266; 1554-527X Schlagwörter: Orthopedics and Sports Medicine Entstehung: Anmerkungen: Beschreibung: <jats:title>Abstract</jats:title><jats:p>Using qualitative and histoquantitative methods, we investigated the effect of immobilization versus nonimmobilization on the biodegradation process, implant‐tissue interaction, and scar formation after enveloping a rejoined rabbit Achilles tendon with a self‐reinforced polyglycolide (SR‐PGA) membrane. The soleus and gastrocnemius tendons of the right hind legs of 40 rabbits were transected. After suturing the ends, the seam was enveloped with the bioabsorbable membrane. Twenty ankles were immobilized with cast, 20 remained nonimmobilized. All nonoperated left ankles served as intact controls. During the follow‐up of 3, 6, 12, and 24 weeks, scar formation, tissue response, and membrane biodegradation were studied histologically and histomorphometrically. The amount of scar tissue, highest at 3 weeks, gradually approached intact controls. SR‐PGA degradation in both cast and noncast specimens was near complete by 24 weeks. Signs of an inflammatory process were most prominent at 3 weeks and diminished gradually by 24 weeks. No significant difference between cast and noncast specimens was noted at any time point regarding the amount of scar tissue, degradation process of PGA, or intensity of inflammatory reaction. In the present experimental setting, cast immobilization influenced neither scar formation nor speed of degradation during reunion of transected Achilles tendon ends as compared with nonimmobilization. No differences in the reunion process of the tendon ends were seen between the immobilized and nonimmobilized groups. Moreover, inflammatory cells were similar in both groups and reflected a transient tissue reaction to the membrane. Within the follow‐up, the seam area (cross‐sectional) approached that of intact controls. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:264–270, 2008</jats:p>