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Grosse, Ulrich; Syha, Roland; Hein, Tobias; Gatidis, Sergios; Grözinger, Gerd; Schabel, Christoph; Martirosian, Petros; Schick, Fritz; Springer, Fabian

Diagnostic value of T1 and T2* relaxation times and off‐resonance saturation effects in the evaluation of achilles tendinopathy by MRI at 3T

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  • Medientyp: E-Artikel
  • Titel: Diagnostic value of T1 and T2* relaxation times and off‐resonance saturation effects in the evaluation of achilles tendinopathy by MRI at 3T
  • Beteiligte: Grosse, Ulrich; Syha, Roland; Hein, Tobias; Gatidis, Sergios; Grözinger, Gerd; Schabel, Christoph; Martirosian, Petros; Schick, Fritz; Springer, Fabian
  • Erschienen: Wiley, 2015
  • Erschienen in: Journal of Magnetic Resonance Imaging
  • Sprache: Englisch
  • DOI: 10.1002/jmri.24657
  • ISSN: 1053-1807; 1522-2586
  • Schlagwörter: Radiology, Nuclear Medicine and imaging
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Purpose</jats:title><jats:p>To evaluate and compare the diagnostic value of T<jats:sub>1</jats:sub>, T<jats:sub>2</jats:sub>* relaxation times and off‐resonance saturation ratios (OSR) in healthy controls and patients with different clinical and morphological stages of Achilles tendinopathy.</jats:p></jats:sec><jats:sec><jats:title>Material and Methods</jats:title><jats:p>Forty‐two healthy Achilles tendons and 34 tendons of 17 patients with symptomatic and asymptomatic tendinopathy were investigated clinically with conventional magnetic resonance imaging (MRI) sequences on a 3T whole‐body MR scanner and a dynamic ultrasound examination. In addition, T<jats:sub>1</jats:sub> and T<jats:sub>2</jats:sub>* relaxation times were assessed using an ultrashort echo time (UTE) imaging sequence with flip angle and echo time variation. For the calculation of OSR values a Gaussian off‐resonance saturation pulse (frequency offset: 750–5000 Hz) was used. The diagnostic value of the derived MR values was assessed and compared using receiver operating characteristic (ROC) curves.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>ROC curves demonstrate the highest overall test performance for OSR values at 2000 Hz off‐resonance in differentiating slightly (OSR‐2000 [AUC: 0.930] &gt; T<jats:sub>2</jats:sub>* [AUC: 0.884] &gt; T<jats:sub>1</jats:sub> [AUC: 0.737]) and more severe pathologically altered tendon areas (OSR‐2000 [AUC: 0.964] &gt; T<jats:sub>2</jats:sub>* [AUC: 0.917] &gt; T<jats:sub>1</jats:sub> [AUC: 0.819]) from healthy ones.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>OSR values at a frequency offset of 2000 Hz demonstrated a better sensitivity and specificity for detecting mild and severe stages of tendinopathy compared to T<jats:sub>2</jats:sub>* and particularly when compared to T<jats:sub>1</jats:sub> relaxation times. <jats:bold>J. Magn. Reson. Imaging 2015;41:964–973</jats:bold>. © <jats:bold>2014 Wiley Periodicals, Inc</jats:bold>.</jats:p></jats:sec>