> Detailanzeige

Chan, John K.; Tewari, Krishnansu S.; Waller, Sarah; Cheung, Michael K.; Shin, Jacob Y.; Osann, Kathryn; Kapp, Daniel S.

The influence of conservative surgical practices for malignant ovarian germ cell tumors

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: The influence of conservative surgical practices for malignant ovarian germ cell tumors
  • Beteiligte: Chan, John K.; Tewari, Krishnansu S.; Waller, Sarah; Cheung, Michael K.; Shin, Jacob Y.; Osann, Kathryn; Kapp, Daniel S.
  • Erschienen: Wiley, 2008
  • Erschienen in: Journal of Surgical Oncology
  • Sprache: Englisch
  • DOI: 10.1002/jso.21079
  • ISSN: 0022-4790; 1096-9098
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate demographics, survival, and surgical trends for patients with malignant ovarian germ cell tumors.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>SEER data abstracted from 1988 to 2001 and analyzed using Kaplan–Meier and Cox regression models.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 760 patients, the median age was 23 years. Seventy‐six percent of patients presented with stage I–II disease, and 24% with stage III–IV. Fifty‐five percent were immature teratomas, 32% dysgerminomas, and 13% yolk sac tumors. Fertility‐preserving surgery was performed in 41.2% (n = 313) of patients. In those &lt;45 years old, the use of fertility‐preserving surgery increased from 40.5% to 44.5% to 48.4% over the time periods 1988–1992, 1993–1997, 1998–2001 (<jats:italic>P</jats:italic> = 0.25). The survival of patients who underwent fertility‐preserving surgery was not statistically different compared to those who underwent standard surgery (<jats:italic>P</jats:italic> = 0.26). Patients with stage I–II disease had improved survival compared to stage III–IV disease (97.6% vs. 85.5%, <jats:italic>P</jats:italic> &lt; 0.001). The overall survival of women with dysgerminomas, immature teratomas, and yolk sac tumors was 99.5%, 94.3%, and 85.4%, respectively (<jats:italic>P</jats:italic> &lt; 0.001). In multivariate analysis, older age, advanced stage, and yolk sac tumor histology predicted for poorer survival.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our data suggests that the use of fertility‐preserving surgery with concomitant surgical staging for germ cell cancers has increased without compromising survival. J. Surg. Oncol. 2008;98:111–116. © 2008 Wiley‐Liss, Inc.</jats:p></jats:sec>