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Mahimkar, Manoj B.; Samant, Tanuja A.; Kannan, Sadhana; Tulsulkar, Jatin; Pai, Prathamesh S.; Anantharaman, Devasena

Polymorphisms in GSTM1 and XPD genes predict clinical outcome in advanced oral cancer patients treated with postoperative radiotherapy

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  • Medientyp: E-Artikel
  • Titel: Polymorphisms in GSTM1 and XPD genes predict clinical outcome in advanced oral cancer patients treated with postoperative radiotherapy
  • Beteiligte: Mahimkar, Manoj B.; Samant, Tanuja A.; Kannan, Sadhana; Tulsulkar, Jatin; Pai, Prathamesh S.; Anantharaman, Devasena
  • Erschienen: Wiley, 2012
  • Erschienen in: Molecular Carcinogenesis
  • Sprache: Englisch
  • DOI: 10.1002/mc.21868
  • ISSN: 0899-1987; 1098-2744
  • Schlagwörter: Cancer Research ; Molecular Biology
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Polymorphisms in metabolic and DNA repair genes may alter protein function, consequently affecting patients' response to chemo/radiotherapy. We retrospectively assessed whether polymorphisms of glutathione‐<jats:italic>S</jats:italic>‐transferase genes <jats:italic>GSTM1</jats:italic> (deletion), <jats:italic>GSTT1</jats:italic> (deletion), <jats:italic>GSTP1</jats:italic> (Ile105Val, rs1695), and DNA repair genes <jats:italic>hOGG1</jats:italic> (Ser326Cys, rs1052133), <jats:italic>XRCC1</jats:italic> (Arg194Trp, rs1799782, and Arg399Gln, rs25487), <jats:italic>XPD</jats:italic> (Asp312Asn, rs1799793, and Lys751Gln, rs13181) can predict clinical outcome in 187 oral squamous cell carcinoma patients treated with postoperative radiotherapy. The Cox proportional hazards model was used to evaluate the role of polymorphic genotypes on relapse‐free (RFS) and disease‐specific (DSS) survival. Deletion polymorphism of <jats:italic>GSTM1</jats:italic> gene was significantly associated with DSS. The rs1799793 variant allele showed significant protection in both DSS and RFS. Significant increase in RFS but not in DSS was observed with polymorphic rs13181. The combined analysis of <jats:italic>GSTM1</jats:italic> and <jats:italic>XPD</jats:italic> polymorphisms revealed favorable effect on survival. <jats:italic>GSTM1</jats:italic> and <jats:italic>XPD</jats:italic> variant alleles, independently as well as in combination may serve as important predictors of clinical outcome in radiotherapy‐treated OSCC patients. © 2011 Wiley Periodicals, Inc.</jats:p>