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Golbe, Lawrence I.; Lazzarini, Alice M.; Spychala, John R.; Johnson, William G.; Stenroos, Edward S.; Mark, Margery H.; Sage, Jacob I.

The tau A0 allele in Parkinson's disease

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  • Medientyp: E-Artikel
  • Titel: The tau A0 allele in Parkinson's disease
  • Beteiligte: Golbe, Lawrence I.; Lazzarini, Alice M.; Spychala, John R.; Johnson, William G.; Stenroos, Edward S.; Mark, Margery H.; Sage, Jacob I.
  • Erschienen: Wiley, 2001
  • Erschienen in: Movement Disorders
  • Sprache: Englisch
  • DOI: 10.1002/mds.1087
  • ISSN: 1531-8257; 0885-3185
  • Schlagwörter: Neurology (clinical) ; Neurology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Parkinson's disease (PD) is primarily an α‐synucle‐ inopathy, rather than a tauopathy, but there is evidence for an indirect association of tau with the pathogenetic process in PD. We therefore assessed the frequency in PD of the tau A0 allele, a dinucleotide repeat marker that has been associated with a sporadic tauopathy, progressive supranuclear palsy (PSP). We found the A0 allele to comprise 79.2% of 758 alleles from PD patients and 71.2% of 264 control alleles (<jats:italic>P</jats:italic> = 0.008). We also performed a meta‐analysis of three previous reports, two of which failed to produce statistically significant results. Taken together, they also support a PD/A0 allelic association, even after correction for misdiagnosis of PSP as PD (<jats:italic>P</jats:italic>&lt; 0.001). The A0/A0 genotype frequency in our patients (62.3%) did not differ significantly from that in controls (53.0%, <jats:italic>P</jats:italic> = 0.062), but the meta‐analysis, even after correction for misdiagnosis, showed a significant result, with <jats:italic>P</jats:italic> = 0.002. The frequency of A0 allele and the A0/A0 genotype were compatible with Hardy‐Weinberg equilibrium. The frequency of the A0 allele and the A0/A0 genotype in our patients with familial PD was not significantly greater than in those with sporadic PD. We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis. © 2001 Movement Disorder Society.</jats:p>