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Medientyp: E-Artikel Titel: Sustained quality‐of‐life improvements over 10 years after deep brain stimulation for dystonia Beteiligte: Hogg, Elliot; During, Emmanuel; E. Tan, Echo; Athreya, Kishore; Eskenazi, Jonathan; Wertheimer, Jeffrey; Mamelak, Adam N.; Alterman, Ron L.; Tagliati, Michele Erschienen: Wiley, 2018 Erschienen in: Movement Disorders, 33 (2018) 7, Seite 1160-1167 Sprache: Englisch DOI: 10.1002/mds.27426 ISSN: 0885-3185; 1531-8257 Entstehung: Anmerkungen: Beschreibung: AbstractBackground: Little is known about the quality of life of people with dystonia and DBS beyond 5 years. The objectives of this study were (1) to examine the long‐term quality‐of‐life outcomes in a large cohort of people with dystonia and DBS, (2) to determine the incidence of stimulation‐induced parkinsonism, and (3) to elucidate the potential long‐term cognitive impact of DBS in this cohort.Methods: Fifty‐four subjects with dystonia and DBS for more than 5 years were contacted via social media and were offered to complete a quality‐of‐life survey comparing current‐day life and life prior to DBS. The primary study outcomes were the Short Form survey, a parkinsonian symptoms questionnaire, the Telephone Montreal Cognitive Assessment, and the Measurement of Every Day Cognition.Results: Thirty‐seven of 54 subjects consented to the study. Average age was 39.7 ± 16.6 years, 16 were female, and 23 were DYT1+. Average time from implantation was 10.5 years. Average total Short Form survey scores improved, from 43.7 pre‐DBS to 69.5 current day (P < 0.0005). Mean total self‐reported parkinsonian symptom score was 13.8 ± 14.7, with worsening balance and hypophonia the most common. Average Telephone Montreal Cognitive Assessment was 20.1 ± 1.6, with 3 of 29 scores (10.3%) in the impaired range (score of 18 or less). Average total Every Day Cognition score was 1.25 ± 0.35, with 3 subjects (10.3%) scoring in the range of impaired cognition (>1.81).Conclusions: DBS for dystonia results in long‐term quality‐of‐life improvements that persist on average 10 years or more after surgery. The prevalence of stimulation‐induced parkinsonism and cognitive impairment is low. © 2018 International Parkinson and Movement Disorder Society