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Travis, Adam R.; Does, Mark D.

Selective excitation of myelin water using inversion–recovery‐based preparations

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  • Medientyp: E-Artikel
  • Titel: Selective excitation of myelin water using inversion–recovery‐based preparations
  • Beteiligte: Travis, Adam R.; Does, Mark D.
  • Erschienen: Wiley, 2005
  • Erschienen in: Magnetic Resonance in Medicine, 54 (2005) 3, Seite 743-747
  • Sprache: Englisch
  • DOI: 10.1002/mrm.20606
  • ISSN: 0740-3194; 1522-2594
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: AbstractT1 and T2 relaxation of excised frog sciatic nerve water was characterized at 7 T. Based on these findings, optimal timings for multiple inversion–recovery magnetization preparations were determined to selectively excite the so‐called myelin–water T2 component. Subsequent double inversion–recovery and triple inversion–recovery preparations were used in combination with CPMG acquisitions to experimentally determine optimal timings and effect of the preparation. Using double inversion–recovery, optimal timings were found to excite magnetization that is predominantly (≈93%) derived from the myelin–water component. Greater selectivity (≈96%) was found by extending the preparation to triple inversion–recovery, at the price of decreasing SNR by a factor of ≈ 2. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.