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Chuang, Kai‐Hsiang; Koretsky, Alan

Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping

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  • Medientyp: E-Artikel
  • Titel: Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping
  • Beteiligte: Chuang, Kai‐Hsiang; Koretsky, Alan
  • Erschienen: Wiley, 2006
  • Erschienen in: Magnetic Resonance in Medicine
  • Sprache: Englisch
  • DOI: 10.1002/mrm.20797
  • ISSN: 0740-3194; 1522-2594
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>There has been growing interest in using manganese‐enhanced MRI (MEMRI) to detect neuronal activation, neural architecture, and neuronal connections. Usually Mn<jats:sup>2+</jats:sup> produces a very wide range of <jats:italic>T</jats:italic><jats:sub>1</jats:sub> change. In particular, in neuronal tract tracing experiments the site of Mn<jats:sup>2+</jats:sup> injection can have very short <jats:italic>T</jats:italic><jats:sub>1</jats:sub> while distant regions have small <jats:italic>T</jats:italic><jats:sub>1</jats:sub> reductions, primarily due to dilution of Mn<jats:sup>2+</jats:sup>. Most MEMRI studies use <jats:italic>T</jats:italic><jats:sub>1</jats:sub>‐weighted sequences, which can only give optimal contrast for a narrow range of <jats:italic>T</jats:italic><jats:sub>1</jats:sub> changes. To improve sensitivity to the full extent of Mn<jats:sup>2+</jats:sup> concentrations and to optimize detection of low concentrations of Mn<jats:sup>2+</jats:sup>, a fast <jats:italic>T</jats:italic><jats:sub>1</jats:sub> mapping sequence based on the Look and Locker technique was implemented. Phantom studies demonstrated less than 6.5% error in <jats:italic>T</jats:italic><jats:sub>1</jats:sub> compared to more conventional <jats:italic>T</jats:italic><jats:sub>1</jats:sub> measurements. Using center‐out segmented EPI, whole‐brain 3D <jats:italic>T</jats:italic><jats:sub>1</jats:sub> maps with 200‐μm isotropic resolution were obtained in 2 h from rat brain. Mn<jats:sup>2+</jats:sup> transport from the rat olfactory bulb through appropriate brain structures could be detected to the amygdala in individual animals. The method reliably detected less than 7% reductions in <jats:italic>T</jats:italic><jats:sub>1</jats:sub>. With this quantitative imaging it should be possible to study more extensive pathways using MEMRI and decrease the dose of Mn<jats:sup>2+</jats:sup> used. Magn Reson Med, 2006. Published 2006 Wiley‐Liss, Inc.</jats:p>