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Huang, Teng‐Yi; Liu, Yi‐Jui; Stemmer, Alto; Poncelet, Brigitte P.

T2 measurement of the human myocardium using a T2‐prepared transient‐state trueFISP sequence

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  • Medientyp: E-Artikel
  • Titel: T2 measurement of the human myocardium using a T2‐prepared transient‐state trueFISP sequence
  • Beteiligte: Huang, Teng‐Yi; Liu, Yi‐Jui; Stemmer, Alto; Poncelet, Brigitte P.
  • Erschienen: Wiley, 2007
  • Erschienen in: Magnetic Resonance in Medicine
  • Sprache: Englisch
  • DOI: 10.1002/mrm.21208
  • ISSN: 1522-2594; 0740-3194
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>A fast and motion‐insensitive technique suitable for myocardial BOLD contrast imaging is presented. The method, termed <jats:italic>T</jats:italic><jats:sub>2</jats:sub>‐TrueFISP, combines <jats:italic>T</jats:italic><jats:sub>2</jats:sub> magnetization preparation with steady‐state free precession (SSFP) imaging for <jats:italic>T</jats:italic><jats:sub>2</jats:sub> relaxation mapping of the myocardium in healthy volunteers. The <jats:italic>T</jats:italic><jats:sub>2</jats:sub> contrast‐to‐noise ratio (CNR) was optimized with the use of transient‐state TrueFISP readout and half‐Fourier readout with linear phase encoding. Single‐slice myocardial <jats:italic>T</jats:italic><jats:sub>2</jats:sub>‐weighted image was obtained within one heartbeat, and a single slice <jats:italic>T</jats:italic><jats:sub>2</jats:sub> map of the myocardium was obtained in under 5–7 s. A respiratory navigator‐gating method was incorporated for serial measurements and signal averaging, with the subjects breathing freely. The mean myocardial <jats:italic>T</jats:italic><jats:sub>2</jats:sub> relaxation time measured in 12 healthy volunteers was 54 ± 5.7 ms. Regional variations of <jats:italic>T</jats:italic><jats:sub>2</jats:sub> values across the myocardium were 7%. Temporal variations across serial <jats:italic>T</jats:italic><jats:sub>2</jats:sub> measurements in a transmural region covering ∼0.5 cc of the left ventricular (LV) wall were 3.6% without signal averaging (number of excitations (NEX) = 1) and 1.7% with signal averaging (NEX = 10). According to our preliminary results, the <jats:italic>T</jats:italic><jats:sub>2</jats:sub>‐TrueFISP method is expected to provide a robust and sensitive tool for clinical application of myocardial BOLD contrast imaging. Magn Reson Med 57:960–966, 2007. © 2007 Wiley‐Liss, Inc.</jats:p>