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Guptill, Jeffrey T.; Barfield, Richard; Chan, Cliburn; Russo, Melissa A.; Emmett, Doug; Raja, Shruti; Massey, Janice M.; Juel, Vern C.; Hobson‐Webb, Lisa D.; Gable, Karissa L.; Gonzalez, Natalia; Hammett, Alex; Howard, James F.; Chopra, Manisha; Kaminski, Henry J.; Siddiqi, Zaeem A.; Migdal, Mattingly; Yi, John S.

Reduced plasmablast frequency is associated with seronegative myasthenia gravis

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  • Medientyp: E-Artikel
  • Titel: Reduced plasmablast frequency is associated with seronegative myasthenia gravis
  • Beteiligte: Guptill, Jeffrey T.; Barfield, Richard; Chan, Cliburn; Russo, Melissa A.; Emmett, Doug; Raja, Shruti; Massey, Janice M.; Juel, Vern C.; Hobson‐Webb, Lisa D.; Gable, Karissa L.; Gonzalez, Natalia; Hammett, Alex; Howard, James F.; Chopra, Manisha; Kaminski, Henry J.; Siddiqi, Zaeem A.; Migdal, Mattingly; Yi, John S.
  • Erschienen: Wiley, 2021
  • Erschienen in: Muscle & Nerve
  • Sprache: Englisch
  • DOI: 10.1002/mus.27140
  • ISSN: 0148-639X; 1097-4598
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The immunopathology of autoimmune seronegative myasthenia gravis (SN MG) is poorly understood. Our objective was to determine immune profiles associated with a diagnosis of SN MG.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed high‐dimensional flow cytometry on blood samples from SN MG patients (N = 68), healthy controls (N = 46), and acetylcholine receptor antibody (AChR+) MG patients (N = 27). We compared 12 immune cell subsets in SN MG to controls using logistic modeling via a discovery‐replication design. An exploratory analysis fit a multinomial model comparing AChR+ MG and controls to SN MG.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>An increase in CD19<jats:sup>+</jats:sup>CD20<jats:sup>−</jats:sup>CD38<jats:sup>hi</jats:sup> plasmablast frequencies was associated with lower odds of being a SN MG case in both the discovery and replication analyses (discovery <jats:italic>P</jats:italic>‐value = .0003, replication <jats:italic>P</jats:italic>‐value = .0021). Interleukin (IL) ‐21 producing helper T cell frequencies were associated with a diagnosis of AChR+ MG (<jats:italic>P</jats:italic> = .004).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Reduced plasmablast frequencies are strongly associated with a SN MG diagnosis and may be a useful diagnostic biomarker in the future.</jats:p></jats:sec>