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Medientyp:
E-Artikel
Titel:
Altered rat skeletal muscle carnitine with age and after denervation
Beteiligte:
Czyzewski, Krzysztof;
Stern, Lawrence Z.;
Sadeh, Menachem;
Bahl, Joseph J.
Erschienen:
Wiley, 1985
Erschienen in:
Muscle & Nerve, 8 (1985) 1, Seite 34-37
Sprache:
Englisch
DOI:
10.1002/mus.880080107
ISSN:
0148-639X;
1097-4598
Entstehung:
Anmerkungen:
Beschreibung:
AbstractWe investigated the effect of denervation on the concentration of total, free, and acyl carnitine in the soleus (S), extensor digitorum longus (EDL), and anterior tibial (AT) muscles of the rat. Soon after denervation there was a marked decrease in total carnitine in all three muscles. Acyl carnitine levels decreased concomitantly with changes in total carnitine. In control but not in denervated muscle, the carnitine concentration was age‐dependent during the period of rapid growth of the animals. The highest carnitine concentration was observed at 14 weeks of age. The results of this study suggest that normal innervation significantly influences carnitine‐mediated lipid metabolism in skeletal muscle.