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Medientyp:
E-Artikel
Titel:
Changes in Visceral Adiposity and Serum Cholesterol with a Novel Viscous Polysaccharide in Japanese Adults with Abdominal Obesity
Beteiligte:
Reimer, Raylene A.;
Yamaguchi, Hideyo;
Eller, Lindsay K.;
Lyon, Michael R.;
Gahler, Roland J.;
Kacinik, Veronica;
Juneja, Prateek;
Wood, Simon
Erschienen:
Wiley, 2013
Erschienen in:Obesity
Sprache:
Englisch
DOI:
10.1002/oby.20435
ISSN:
1930-7381;
1930-739X
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p><jats:bold>Objective:</jats:bold> Evidence supports the role of dietary fiber in improving metabolic health. PolyGlycopleX<jats:sup>®</jats:sup> (PGX<jats:sup>®</jats:sup>), a viscous functional polysaccharide improves lipidemia and glycemia in healthy adults. Our objective was to examine the effects of PGX<jats:sup>®</jats:sup> on risk factors associated with the metabolic syndrome in Japanese adults with abdominal obesity.</jats:p><jats:p><jats:bold>Design and Methods:</jats:bold> Sixty four subjects assigned to 14 weeks of 15 g day<jats:sup>−1</jats:sup> of PGX<jats:sup>®</jats:sup> or placebo were assessed in a randomized, double‐blind, placebo‐controlled, parallel group trial. At week 0 and 14, primary outcome measures were serum lipids, abdominal adiposity, glucose tolerance and blood pressure.</jats:p><jats:p><jats:bold>Results:</jats:bold> Total and LDL cholesterol were reduced at week 14 with PGX<jats:sup>®</jats:sup> but not placebo (<jats:italic>P</jats:italic> < 0.05). The reduction in waist circumference at week 14 was greater with PGX<jats:sup>®</jats:sup> versus placebo (<jats:italic>P</jats:italic> < 0.05). In females, abdominal visceral fat was decreased to a greater extent with PGX<jats:sup>®</jats:sup> versus placebo (<jats:italic>P</jats:italic> < 0.05). While glucose tolerance worsened with placebo over time, PGX<jats:sup>®</jats:sup> reduced glucose total area under the curve from week 0 to 6 (<jats:italic>P</jats:italic> = 0.039). Serum concentrations of resistin and IL6 increased slightly in placebo and decreased slightly with PGX<jats:sup>®</jats:sup>.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold> PGX<jats:sup>®</jats:sup> is a functional fiber that shows promise in reducing risk factors related to the metabolic syndrome in Japanese adults with abdominal obesity.</jats:p>