• Medientyp: E-Artikel
  • Titel: Interfering effect of maternal cell contamination on invasive prenatal molecular genetic testing
  • Beteiligte: Koczok, Katalin; Gombos, Éva; Madar, László; Török, Olga; Balogh, István
  • Erschienen: Wiley, 2018
  • Erschienen in: Prenatal Diagnosis
  • Sprache: Englisch
  • DOI: 10.1002/pd.5319
  • ISSN: 0197-3851; 1097-0223
  • Schlagwörter: Genetics (clinical) ; Obstetrics and Gynecology
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  • Beschreibung: <jats:p>What is already known about this topic? <jats:list list-type="bullet"> <jats:list-item><jats:p>Analytical sensitivity of the studied molecular genetic methods such as Sanger DNA sequencing, multiplex ligation‐dependent probe amplification, and next‐generation sequencing has been studied previously in relation to somatic mosaicism testing.</jats:p></jats:list-item> </jats:list></jats:p><jats:p>What does this study add? <jats:list list-type="bullet"> <jats:list-item><jats:p>We determine significant maternal cell contamination levels for these molecular genetic techniques in a comprehensive way and also evaluate previously published data in the context of maternal cell contamination and prenatal molecular testing.</jats:p></jats:list-item> </jats:list></jats:p>