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Stephan, Carsten; Xu, Chuanliang; Brown, David A.; Breit, Samuel N.; Michael, Anja; Nakamura, Terukazu; Diamandis, Eleftherios P.; Meyer, Hellmuth; Cammann, Henning; Jung, Klaus

Three new serum markers for prostate cancer detection within a percent free PSA‐based artificial neural network

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  • Medientyp: E-Artikel
  • Titel: Three new serum markers for prostate cancer detection within a percent free PSA‐based artificial neural network
  • Beteiligte: Stephan, Carsten; Xu, Chuanliang; Brown, David A.; Breit, Samuel N.; Michael, Anja; Nakamura, Terukazu; Diamandis, Eleftherios P.; Meyer, Hellmuth; Cammann, Henning; Jung, Klaus
  • Erschienen: Wiley, 2006
  • Erschienen in: The Prostate
  • Sprache: Englisch
  • DOI: 10.1002/pros.20381
  • ISSN: 0270-4137; 1097-0045
  • Schlagwörter: Urology ; Oncology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>BACKGROUND</jats:title><jats:p>We aimed to evaluate the value of macrophage inhibitory cytokine 1 (MIC‐1), human kallikrein 11 (hK11) migration inhibitor factor (MIF) in comparison to prostate‐specific antigen (PSA) and %fPSA and also to develop a %fPSA‐based ANN with the new input factors to determine whether these additional markers can further eliminate unnecessary prostate biopsies.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>Serum samples from 371 patients with prostate cancer (PCa, n = 135) or benign prostate hyperplasia (BPH, n = 236) within the PSA range 0.5–20 µg/L were analyzed for total PSA, free PSA, MIC‐1, hK11, and MIF. ‘Leave one out’ ANN models with these variables and prostate volume were constructed and compared to logistic regression (LR) and all single parameters.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>The discriminatory power of MIC‐1, hK11, and MIF was less than that for PSA despite significant differences in BPH compared to PCa patients. At 90% and 95% sensitivity, the artificial neural networks (ANNs) were only significantly better than %fPSA if prostate volume was included.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>ANNs with the novel input factors of MIC‐1, MIF, and/or hK11 and additional use of prostate volume demonstrated significant advantage compared with %fPSA and tPSA and may lead to a reduction in unnecessary prostate biopsies. Prostate 66:651–659, 2006. © 2005 Wiley‐Liss, Inc.</jats:p></jats:sec>