About nitrile‐formamide‐chloride‐adducts. IX. Synthesis of 1,3‐ or 1,5‐disubstituted 1,2,4‐triazoles by the reaction of nitrile‐formamide chloride‐adducts and their products of hydrolysis with hydrazines
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Medientyp:
E-Artikel
Titel:
About nitrile‐formamide‐chloride‐adducts. IX. Synthesis of 1,3‐ or 1,5‐disubstituted 1,2,4‐triazoles by the reaction of nitrile‐formamide chloride‐adducts and their products of hydrolysis with hydrazines
Beteiligte:
Liebscher, Jürgen;
Rumler, Andrea
Erschienen:
Wiley, 1984
Erschienen in:Journal für Praktische Chemie
Sprache:
Englisch
DOI:
10.1002/prac.19843260216
ISSN:
0021-8383
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>2‐Aza‐3‐chloro‐2‐propeniminium salts <jats:bold>5</jats:bold>, which are easily available by the addition of formamide chlorides <jats:bold>1</jats:bold> to nitriles <jats:bold>2</jats:bold> react smoothly with hydrazines <jats:bold>9</jats:bold> giving rise to 1,3‐disubstituted 1,2,4,‐triazoles <jats:bold>11</jats:bold>. When the 2‐aza‐3‐chloro‐2‐propeniminium salts <jats:bold>5</jats:bold> are hydrolysed first the resulting N‐acyl‐formamidinium salts <jats:bold>6</jats:bold> react with hydrazines <jats:bold>9</jats:bold> to 1,5 disubstituted 1,2,4‐triazoles <jats:bold>13</jats:bold> via isolable N‐acyl‐formamidrazones <jats:bold>12</jats:bold>.</jats:p>