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Medientyp: E-Artikel Titel: Resistance evolution in Drosophila: the case of CYP6G1 Beteiligte: Le Goff, Gaelle; Hilliou, Frédérique Erschienen: Wiley, 2017 Erschienen in: Pest Management Science Sprache: Englisch DOI: 10.1002/ps.4470 ISSN: 1526-498X; 1526-4998 Schlagwörter: Insect Science ; Agronomy and Crop Science ; General Medicine Entstehung: Anmerkungen: Beschreibung: <jats:title>Abstract</jats:title><jats:p>The massive use of <jats:styled-content style="fixed-case">DDT</jats:styled-content> as an insecticide between 1940 and 1970 has resulted in the emergence of a resistant population of insects. One of the main metabolic mechanisms developed by resistant insects involves detoxification enzymes such as cytochrome <jats:styled-content style="fixed-case">P450</jats:styled-content>s. These enzymes can metabolise the insecticide to render it less toxic and facilitate its elimination from the organism. The P450 <jats:italic>Cyp6g1</jats:italic> was identified as the major factor responsible for <jats:styled-content style="fixed-case">DDT</jats:styled-content> resistance in <jats:italic>Drosophila melanogaster</jats:italic> field populations. In this article, we review the data available for this gene since it was associated with resistance in 2002. The knowledge gained on <jats:italic>Cyp6g1</jats:italic> allows a better understanding of the evolution of insecticide resistance mechanisms and highlights the major role of transposable elements in evolutionary processes. © 2016 Society of Chemical Industry</jats:p>