A stochastic model for microtubule dynamicity involving mixtures of tubulin isotypes

Medientyp: E-Artikel
Titel: A stochastic model for microtubule dynamicity involving mixtures of tubulin isotypes
Beteiligte: Rezania, Vahid; Tuszynski, Jack A.
Erschienen: Wiley, 2009
Erschienen in: International Journal of Quantum Chemistry
Sprache: Englisch
DOI: 10.1002/qua.21986
ISSN: 0020-7608; 1097-461X
Schlagwörter: Physical and Theoretical Chemistry ; Condensed Matter Physics ; Atomic and Molecular Physics, and Optics
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>Experimental studies on the dynamicity of microtubules in a mixed αβ<jats:sub>II</jats:sub>/αβ<jats:sub>III</jats:sub> tubulin solution show a nonlinear dependence with respect to the relative αβ<jats:sub>II</jats:sub>/αβ<jats:sub>III</jats:sub> concentration. In this article, a physical model explaining this phenomenon in terms of tubulin dimers' affinity is introduced. We argue that lower affinities of tubulin dimers belonging to the same isotype than those that represent different isotypes indicate hitherto unsuspected influences of tubulin dimers on each other within a microtubule. We further show that similar influences between GTP‐GTP, GTP‐GDP, and GDP‐GDP tubulin dimers could also play a major role in the structure of the microtubule tip and hence in determining the microtubule's growth and/or shortening phases. These results can guide a future atomistic‐level model development. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2009</jats:p>

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