Beschreibung:
AbstractThe high prevalence and innate resistance of S. aureus biofilm towards antibiotics underscores a critical need for antibiofilm therapeutics. In this regard, membrane‐targeting bactericidal synthetic amphiphiles emerge as attractive candidates for anti‐staphylococcal therapy. In order to harness the potential of bactericidal amphiphiles for mitigation of Staphylococcus biofilm, an efficient delivery system needs to be developed, which is biocompatible and supports efficient loading and delivery of the antibiofilm cargo. In line with this rationale, the present investigation is an endeavor towards the generation of a bactericidal amphiphile‐loaded iron‐doped zinc oxide nanocomposite (C1‐FeZNP2) that exhibited superior cytocompatibility, facilitated sustained release of the payload and displayed antagonistic activity against S. aureus biofilm. Interestingly, the antibiofilm potential of the nanocomposite in combination with vancomycin against a clinical strain of methicillin‐resistant S. aureus (MRSA) could also be captured in the present study.