Effects of haloperidol and clozapine on preprotachykinin‐A messenger RNA, tachykinin tissue levels, release and neurokinin‐1 receptors in the striato‐nigral system
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Titel:
Effects of haloperidol and clozapine on preprotachykinin‐A messenger RNA, tachykinin tissue levels, release and neurokinin‐1 receptors in the striato‐nigral system
Beschreibung:
AbstractThe effects of haloperidol and clozapine on tachykinin tissue lelvels, preprotachykinin‐A messenger RNA, spontaneous and potassium‐evoked tachykinin release, dopamine D2 receptors, and [125]Bolton‐Hunter‐substance P binding sites in the striato‐nigral system were examined. Chronic administration (10 days) of the dopamine receptor antagonist haloperidol (2 mg/kg, i.p.) significantly decreased tissue levels of substance P like‐immunoreactivity and neurokinin A like‐immunoreactivity in the striatum and the substantia nigra. The corresponding preprotachykinin‐A mRNA was decreased ub tge struatyun, Haloperidol did not affect the potassium‐evoked tachyikinin release in the substantia nigra but significantly increased the spontaneous release. Haloperidol increased the number of D2‐receptors but left [125]Bolton‐Hunter‐substance P binding sites, representing neurokinin 1 (NK‐1) receptors, as determined by competition experiments with selective ligands, unchanged. Clozapine (30 mg/kg, i.m.) did not influence nigral and striatal tachykinin tissue levels, preprotachykinin‐A mRNA and potassium‐evoked release or spontaneous efflux in the substantia nigra, or D2‐receptors and [125I]Bolton‐Hunter‐substance P bindin sites. The present data indicate that neuroleptics influence the striato‐nigral tachykinin system in different ways. Tachykinins may therefore, contribute to the therapeutic and/or untoward effects of certain neuroleptic drugs.