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Medientyp:
E-Artikel
Titel:
Lecture Notes in Computer Science: Graph-Based Methods for Rational Drug Design
Beteiligte:
Droschinsky, Andre;
Humbeck, Lina;
Koch, Oliver;
Kriege, Nils M.;
Mutzel, Petra;
Schäfer, Till
Erschienen:
Springer Nature Switzerland, 2022
Erschienen in:Lecture Notes in Computer Science
Sprache:
Nicht zu entscheiden
DOI:
10.1007/978-3-031-21534-6_5
ISSN:
0302-9743;
1611-3349
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Rational drug design deals with computational methods to accelerate the development of new drugs. Among other tasks, it is necessary to analyze huge databases of small molecules. Since a direct relationship between the structure of these molecules and their effect (e.g., toxicity) can be assumed in many cases, a wide set of methods is based on the modeling of the molecules as graphs with attributes.</jats:p><jats:p>Here, we discuss our results concerning <jats:italic>structural</jats:italic> molecular similarity searches and molecular clustering and put them into the wider context of graph similarity search. In particular, we discuss algorithms for computing graph similarity w.r.t. maximum common subgraphs and their extension to domain specific requirements.</jats:p>