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Sun, Rui; Fietz, Julia; Erhart, Mira; Poehlchen, Dorothee; Henco, Lara; Brückl, Tanja M.; Binder, Elisabeth B.; Erhardt, Angelika; Lucae, Susanne; Grandi, Norma C.; Namendorf, Tamara; Elbau, Immanuel; Leuchs, Laura; Brem, Anna Katharine; Schilbach, Leonhard; Ilić-Ćoćić, Sanja; Ziebula, Julius; von Mücke-Heim, Iven-Alex; Kim, Yeho; Pape, Julius; Czisch, Michael; Saemann, Philipp G.; Spoormaker, Victor I.

Free-viewing gaze patterns reveal a mood-congruency bias in MDD during an affective fMRI/eye-tracking task

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  • Medientyp: E-Artikel
  • Titel: Free-viewing gaze patterns reveal a mood-congruency bias in MDD during an affective fMRI/eye-tracking task
  • Beteiligte: Sun, Rui; Fietz, Julia; Erhart, Mira; Poehlchen, Dorothee; Henco, Lara; Brückl, Tanja M.; Binder, Elisabeth B.; Erhardt, Angelika; Lucae, Susanne; Grandi, Norma C.; Namendorf, Tamara; Elbau, Immanuel; Leuchs, Laura; Brem, Anna Katharine; Schilbach, Leonhard; Ilić-Ćoćić, Sanja; Ziebula, Julius; von Mücke-Heim, Iven-Alex; Kim, Yeho; Pape, Julius; Czisch, Michael; Saemann, Philipp G.; Spoormaker, Victor I.
  • Erschienen: Springer Science and Business Media LLC, 2024
  • Erschienen in: European Archives of Psychiatry and Clinical Neuroscience
  • Sprache: Englisch
  • DOI: 10.1007/s00406-023-01608-8
  • ISSN: 0940-1334; 1433-8491
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Major depressive disorder (MDD) has been related to abnormal amygdala activity during emotional face processing. However, a recent large-scale study (<jats:italic>n</jats:italic> = 28,638) found no such correlation, which is probably due to the low precision of fMRI measurements. To address this issue, we used simultaneous fMRI and eye-tracking measurements during a commonly employed emotional face recognition task. Eye-tracking provide high-precision data, which can be used to enrich and potentially stabilize fMRI readouts. With the behavioral response, we additionally divided the active task period into a task-related and a free-viewing phase to explore the gaze patterns of MDD patients and healthy controls (HC) and compare their respective neural correlates. Our analysis showed that a mood-congruency attentional bias could be detected in MDD compared to healthy controls during the free-viewing phase but without parallel amygdala disruption. Moreover, the neural correlates of gaze patterns reflected more prefrontal fMRI activity in the free-viewing than the task-related phase. Taken together, spontaneous emotional processing in free viewing might lead to a more pronounced mood-congruency bias in MDD, which indicates that combined fMRI with eye-tracking measurement could be beneficial for our understanding of the underlying psychopathology of MDD in different emotional processing phases.</jats:p><jats:p><jats:italic>Trial Registration</jats:italic>: The BeCOME study is registered on ClinicalTrials (gov: NCT03984084) by the Max Planck Institute of Psychiatry in Munich, Germany.</jats:p>