Language impairment in the genetic forms of behavioural variant frontotemporal dementia

Medientyp: E-Artikel
Titel: Language impairment in the genetic forms of behavioural variant frontotemporal dementia
Beteiligte: Samra, Kiran; MacDougall, Amy M.; Bouzigues, Arabella; Bocchetta, Martina; Cash, David M.; Greaves, Caroline V.; Convery, Rhian S.; van Swieten, John C.; Seelaar, Harro; Jiskoot, Lize; Moreno, Fermin; Sanchez-Valle, Raquel; Laforce, Robert; Graff, Caroline; Masellis, Mario; Tartaglia, Maria Carmela; Rowe, James B.; Borroni, Barbara; Finger, Elizabeth; Synofzik, Matthis; Galimberti, Daniela; Vandenberghe, Rik; de Mendonça, Alexandre; Butler, Christopher R.; [...]
Erschienen: Springer Science and Business Media LLC, 2023
Erschienen in: Journal of Neurology
Sprache: Englisch
DOI: 10.1007/s00415-022-11512-1
ISSN: 0340-5354; 1432-1459
Schlagwörter: Neurology (clinical) ; Neurology
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Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Behavioural variant fronto-temporal dementia (bvFTD) is characterised by a progressive change in personality in association with atrophy of the frontal and temporal lobes. Whilst language impairment has been described in people with bvFTD, little is currently known about the extent or type of linguistic difficulties that occur, particularly in the genetic forms.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Participants with genetic bvFTD along with healthy controls were recruited from the international multicentre Genetic FTD Initiative (GENFI). Linguistic symptoms were assessed using items from the Progressive Aphasia Severity Scale (PASS). Additionally, participants undertook the Boston Naming Test (BNT), modified Camel and Cactus Test (mCCT) and a category fluency test. Participants underwent a 3T volumetric T1-weighted MRI, with language network regional brain volumes measured and compared between the genetic groups and controls. </jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>76% of the genetic bvFTD cohort had impairment in at least one language symptom: 83% <jats:italic>C9orf72</jats:italic>, 80% <jats:italic>MAPT</jats:italic> and 56% <jats:italic>GRN</jats:italic> mutation carriers. All three genetic groups had significantly impaired functional communication, decreased fluency, and impaired sentence comprehension. <jats:italic>C9orf72</jats:italic> mutation carriers also had significantly impaired articulation and word retrieval as well as dysgraphia whilst the <jats:italic>MAPT</jats:italic> mutation group also had impaired word retrieval and single word comprehension. All three groups had difficulties with naming, semantic knowledge and verbal fluency. Atrophy in key left perisylvian language regions differed between the groups, with generalised involvement in the <jats:italic>C9orf72</jats:italic> group and more focal temporal and insula involvement in the other groups. Correlates of language symptoms and test scores also differed between the groups. </jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Language deficits exist in a substantial proportion of people with familial bvFTD across all three genetic groups. Significant atrophy is seen in the dominant perisylvian language areas and correlates with language impairments within each of the genetic groups. Improved understanding of the language phenotype in the main genetic bvFTD subtypes will be helpful in future studies, particularly in clinical trials where accurate stratification and monitoring of disease progression is required. </jats:p> </jats:sec>

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