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James, Steven; Perry, Lin; Lowe, Julia; Donaghue, Kim C.; Pham-Short, Anna; Craig, Maria E.; Ambler, Geoff; Anderson, Kym; Andrikopoulos, Sof; Batch, Jenny; Brown, Justin; Cameron, Fergus; Colman, Peter G.; Conwell, Louise; Cotterill, Andrew; Couper, Jennifer; Davis, Elizabeth; de Bock, Martin; Fairchild, Jan; Fegan, Gerry; Fourlanos, Spiros; Glastras, Sarah; Goss, Peter; Gray, Leonie; [...]

Coexisiting type 1 diabetes and celiac disease is associated with lower Hba1c when compared to type 1 diabetes alone: data from the Australasian Diabetes Data Network (ADDN) registry

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  • Medientyp: E-Artikel
  • Titel: Coexisiting type 1 diabetes and celiac disease is associated with lower Hba1c when compared to type 1 diabetes alone: data from the Australasian Diabetes Data Network (ADDN) registry
  • Beteiligte: James, Steven; Perry, Lin; Lowe, Julia; Donaghue, Kim C.; Pham-Short, Anna; Craig, Maria E.; Ambler, Geoff; Anderson, Kym; Andrikopoulos, Sof; Batch, Jenny; Brown, Justin; Cameron, Fergus; Colman, Peter G.; Conwell, Louise; Cotterill, Andrew; Couper, Jennifer; Davis, Elizabeth; de Bock, Martin; Fairchild, Jan; Fegan, Gerry; Fourlanos, Spiros; Glastras, Sarah; Goss, Peter; Gray, Leonie; [...]
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Acta Diabetologica
  • Sprache: Englisch
  • DOI: 10.1007/s00592-023-02113-z
  • ISSN: 1432-5233
  • Schlagwörter: Endocrinology ; General Medicine ; Endocrinology, Diabetes and Metabolism ; Internal Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Aim</jats:title> <jats:p>To compare HbA1c and clinical outcomes in adolescents and young adults with type 1 diabetes (T1D), with or without celiac disease (CD).</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Longitudinal data were extracted from ADDN, a prospective clinical diabetes registry. Inclusion criteria were T1D (with or without CD), ≥ 1 HbA1c measurement, age 16–25 years and diabetes duration ≥ 1 year at last measurement. Multivariable Generalised Estimated Equation models were used for longitudinal analysis of variables associated with HbA1c.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Across all measurements, those with coexisting T1D and CD had lower HbA1c when compared to those with T1D alone (8.5 ± 1.5% (69.4 ± 16.8 mmol/mol) vs. 8.7 ± 1.8% (71.4 ± 19.8 mmol/mol); <jats:italic>p</jats:italic> &lt; 0.001); lower HbA1c was associated with shorter diabetes duration (B = − 0.06; 95% CI − 0.07 to − 0.05; <jats:italic>p</jats:italic> &lt; 0.001), male sex (B = − 0.24; − 0.36 to − 0.11; <jats:italic>p</jats:italic> &lt; 0.001), insulin pump therapy use (B = − 0.46; − 0.58 to − 0.34; <jats:italic>p</jats:italic> &lt; 0.001), coexistence of T1D and CD (B = − 0.28; − 0.48 to − 0.07; <jats:italic>p</jats:italic> = 0.01), blood pressure (B = − 0.16; − 0.23 to − 0.09; <jats:italic>p</jats:italic> &lt; 0.001) and body mass index (B = -− 0.03; − 0.02 to − 0.04; <jats:italic>p</jats:italic> = 0.01) in the normal range. At last measurement, 11.7% of the total population had a HbA1c &lt; 7.0% (53.0 mmol/mol).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Across all measurements, coexisting T1D and CD is associated with lower HbA1c when compared to T1D alone. However, HbA1c is above target in both groups.</jats:p> </jats:sec>