Erschienen:
Springer Science and Business Media LLC, 2023
Erschienen in:
Clinical Oral Investigations, 27 (2023) 8, Seite 4803-4808
Sprache:
Englisch
DOI:
10.1007/s00784-023-05109-9
ISSN:
1436-3771
Entstehung:
Anmerkungen:
Beschreibung:
Abstract Objectives Observational studies suggested an inverse association between physical activity and periodontitis. However, observational studies might be subject to unobserved confounding and reverse causation bias. We conducted an instrumental variable study to strengthen the evidence on the relationship between physical activity and periodontitis. Materials and methods We used genetic variants associated with self-reported and accelerometer-assessed physical activity in 377,234 and 91,084 UK Biobank participants, respectively, as instruments. For these instruments, genetic associations with periodontitis were obtained from 17,353 cases and 28,210 controls in the GeneLifestyle Interactions in Dental Endpoints consortium. Results We found no evidence for effects of self-reported moderate-to-vigorous physical activity, self-reported vigorous physical activity, accelerometry “average accelerations,” and “fraction of accelerations > 425 milli-gravities” on periodontitis. For example, the odds ratio for self-reported moderate-to-vigorous physical activity was 1.07 (95% credible interval: 0.87; 1.34) in Causal Analysis using Summary Effect Estimates. We conducted sensitivity analyses to rule out weak instrument bias and correlated horizontal pleiotropy. Conclusions The study does not support an effect of physical activity on the risk of periodontitis. Clinical relevance This study provides little evidence that recommending physical activity would help prevent periodontitis.