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Goller, Sophia Samira; Reidler, Paul; Rudolph, Jan; Rückel, Johannes; Hesse, Nina; Schmidt, Vanessa Franziska; Dürr, Hans Roland; Klein, Alexander; Lindner, Lars Hartwin; Di Gioia, Dorit; Kuhn, Isabella; Ricke, Jens; Erber, Bernd

Impact of postoperative baseline MRI on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb

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  • Medientyp: E-Artikel
  • Titel: Impact of postoperative baseline MRI on diagnostic confidence and performance in detecting local recurrence of soft-tissue sarcoma of the limb
  • Beteiligte: Goller, Sophia Samira; Reidler, Paul; Rudolph, Jan; Rückel, Johannes; Hesse, Nina; Schmidt, Vanessa Franziska; Dürr, Hans Roland; Klein, Alexander; Lindner, Lars Hartwin; Di Gioia, Dorit; Kuhn, Isabella; Ricke, Jens; Erber, Bernd
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Skeletal Radiology
  • Sprache: Englisch
  • DOI: 10.1007/s00256-023-04341-4
  • ISSN: 0364-2348; 1432-2161
  • Schlagwörter: Radiology, Nuclear Medicine and imaging
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title> Abstract</jats:title><jats:sec> <jats:title>Objective</jats:title> <jats:p>To evaluate the impact of a postoperative baseline (PB) MRI on diagnostic confidence and performance in detecting local recurrence (LR) of soft-tissue sarcoma (STS) of the limb.</jats:p> </jats:sec><jats:sec> <jats:title>Materials and methods</jats:title> <jats:p>A total of 72 patients (8 with LR, 64 without LR) with primary STS of the limb were included. Routine follow-up MRI (1.5 T) at 6 and approximately 36 months (mean<jats:sub>LR</jats:sub>: 39.7 months; mean<jats:sub>no LR</jats:sub>: 34.9 months) after multimodal therapy or at time of LR were assessed by three independent readers using a 5-point Likert scale. Furthermore, the following imaging parameters were evaluated: presence of a mass, signal characteristics at T2- and T1-weighted imaging, contrast enhancement (CE), and in some of the cases signal intensity on the apparent diffusion coefficient (ADC). U-test, McNemar test, and ROC-analysis were applied. Interobserver reliability was calculated using Fleiss kappa statistics. A <jats:italic>p</jats:italic> value of 0.05 was considered statistically significant.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>The presence of a PB MRI significantly improved diagnostic confidence in detecting LR of STS (<jats:italic>p</jats:italic> &lt; 0.001) and slightly increased specificity (mean specificity without PE 74.1% and with presence of PB MRI 81.2%); however, not to a significant level. The presence of a mass showed highest diagnostic performance and highest interreader agreement (AUC [%]; <jats:italic>κ</jats:italic>: 73.1–83.6; 0.34) followed by T2-hyperintensity (50.8–66.7; 0.08), CE (52.4–62.5; 0.13), and T1-hypointensity (54.7–77.3; 0.23). ADC showed an AUC of 65.6–96.6% and a <jats:italic>κ</jats:italic> of 0.55.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The presence of a PB MRI increases diagnostic confidence in detecting LR of STS of the limb.</jats:p> </jats:sec>