Erschienen:
Springer Science and Business Media LLC, 2022
Erschienen in:European Journal of Nutrition
Sprache:
Englisch
DOI:
10.1007/s00394-022-02827-w
ISSN:
1436-6207;
1436-6215
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>This study investigated whether UVB-exposed wheat germ oil (WGO) is capable to improving the vitamin D status in healthy volunteers.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>A randomized controlled human-intervention trial in parallel design was conducted in Jena (Germany) between February and April. Ultimately, 46 healthy males and females with low mean 25-hydroxyvitamin D (25(OH)D) levels (34.9 ± 10.6 nmol/L) were randomized into three groups receiving either no WGO oil (control, <jats:italic>n</jats:italic> = 14), 10 g non-exposed WGO per day (– UVB WGO, <jats:italic>n</jats:italic> = 16) or 10 g WGO, which was exposed for 10 min to ultraviolet B-light (UVB, intensity 500–630 µW/cm<jats:sup>2</jats:sup>) and provided 23.7 µg vitamin D (22.9 µg vitamin D<jats:sub>2</jats:sub> and 0.89 µg vitamin D<jats:sub>3</jats:sub>) (+ UVB WGO, <jats:italic>n</jats:italic> = 16) for 6 weeks. Blood was obtained at baseline, after 3 and 6 weeks and analyzed for serum vitamin D-metabolite concentrations via LC–MS/MS.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>Participants who received the UVB-exposed WGO were characterized by an increase of circulating 25(OH)D<jats:sub>2</jats:sub> after 3 and 6 weeks of intervention. However, the 25(OH)D<jats:sub>3</jats:sub> concentrations decreased in the + UVB WGO group, while they increased in the control groups. Finally, the total 25(OH)D concentration (25(OH)D<jats:sub>2</jats:sub> + 25(OH)D<jats:sub>3</jats:sub>) in the + UVB WGO group was lower than that of the non-WGO receiving control group after 6 weeks of treatment. In contrast, circulating vitamin D (vitamin D<jats:sub>2</jats:sub> + vitamin D<jats:sub>3</jats:sub>) was higher in the + UVB WGO group than in the control group receiving no WGO.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>UVB-exposed WGO containing 23.7 µg vitamin D can increase 25(OH)D<jats:sub>2</jats:sub> levels but do no improve total serum levels of 25(OH)D of vitamin D-insufficient subjects.</jats:p>
</jats:sec><jats:sec>
<jats:title>Trial registration</jats:title>
<jats:p>ClinicalTrials.gov: NCT03499327 (registered, April 13, 2018).</jats:p>
</jats:sec>