• Medientyp: E-Artikel
  • Titel: Differences in antibody levels to H. pylori virulence factors VacA and CagA among African Americans and whites in the Southeast USA
  • Beteiligte: Butt, Julia; Blot, William J.; Shrubsole, Martha J.; Waterboer, Tim; Pawlita, Michael; Epplein, Meira
  • Erschienen: Springer Science and Business Media LLC, 2020
  • Erschienen in: Cancer Causes & Control
  • Sprache: Englisch
  • DOI: 10.1007/s10552-020-01295-z
  • ISSN: 0957-5243; 1573-7225
  • Schlagwörter: Cancer Research ; Oncology
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p><jats:italic>Helicobacter pylori</jats:italic> (<jats:italic>H. pylori</jats:italic>) is the leading cause of gastric cancer. High antibody levels to <jats:italic>H. pylori</jats:italic> virulence factors Vacuolating cytotoxin A (VacA) and Cytotoxin-associated gene A (CagA) have been suggested as gastric cancer risk markers. In the USA, <jats:italic>H. pylori</jats:italic> sero-prevalence is twofold higher in African Americans compared to whites. We sought to assess whether African Americans also exhibit higher antibody levels to VacA and CagA.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Antibody responses to <jats:italic>H. pylori</jats:italic> proteins were measured by multiplex serology in 686 African Americans and whites of the Southern Community Cohort Study. Among VacA- and CagA-seropositives, we analyzed the association of race with antibody level using logistic regression models to produce odds ratios (OR) and 95% confidence intervals (CI).</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Sero-positive African Americans had significantly higher mean antibody levels to both VacA and CagA, which resulted in increased odds for the highest quartile of antibody levels compared to sero-positive whites (VacA, OR: 6.08; 95% CI 3.41, 10.86; CagA, OR: 3.77; 95% CI 1.61, 8.84).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Our findings support future studies to assess the association of differential antibody responses by race with risk of gastric cancer in the USA, which could then aid in developing targeted <jats:italic>H. pylori</jats:italic> eradication strategies.</jats:p> </jats:sec>