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Bauer, David; Farthofer, Anna; Chromy, David; Simbrunner, Benedikt; Steininger, Lisa; Schmidbauer, Caroline; Binter, Teresa; Trauner, Michael; Mandorfer, Mattias; Schmidt, Ralf; Mayer, Florian; Holzmann, Heidemarie; Strassl, Robert; Reiberger, Thomas

Recent outbreaks of severe hepatitis A virus infections in Vienna

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  • Medientyp: E-Artikel
  • Titel: Recent outbreaks of severe hepatitis A virus infections in Vienna
  • Beteiligte: Bauer, David; Farthofer, Anna; Chromy, David; Simbrunner, Benedikt; Steininger, Lisa; Schmidbauer, Caroline; Binter, Teresa; Trauner, Michael; Mandorfer, Mattias; Schmidt, Ralf; Mayer, Florian; Holzmann, Heidemarie; Strassl, Robert; Reiberger, Thomas
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases
  • Sprache: Englisch
  • DOI: 10.1007/s10096-020-04028-x
  • ISSN: 0934-9723; 1435-4373
  • Schlagwörter: Infectious Diseases ; Microbiology (medical) ; General Medicine
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>To explore the epidemiology and clinical course of hepatitis A virus (HAV) infections at the Vienna General Hospital. We retrospectively identified patients who were tested positive for HAV-IgM at the Vienna General Hospital form Q1/2008 to Q3/2018. Our definition of severe HAV infection was AST and/or ALT &gt; 5 × above the upper limit of normal (ULN); and liver dysfunction as (i) hepatic encephalopathy or ammonia &gt; 100 μmol/L, (ii) coagulopathy with INR &gt; 1.5, or (iii) jaundice with bilirubin &gt; 5 mg/dL. A total of 578 HAV-IgM (+) were identified, including 31 (5.4%) and 38 (6.6%) without and with liver dysfunction, respectively. A proportional increase in severe HAV cases with and without liver dysfunction occurred in 2016/2017 with (21.5% (vs. 8.0% in the years before; <jats:italic>p</jats:italic> &lt; 0.001). Thirty-seven (53.6%) patients with severe HAV were hospitalized, 6 (9%) required ICU support, and one patient received liver transplantation within 30 days. Patients with severe HAV and liver dysfunction were more often male (60.5 vs. 43.1%, <jats:italic>p</jats:italic> = 0.055) and younger (31.5 vs. 63 years, <jats:italic>p</jats:italic> &lt; 0.001) as compared with other HAV-IgM (+) cases. The observed increase of severe HAV infections in Vienna in 2017 among young males, coincided with a multinational HAV outbreak among MSM. Our data suggests a higher likelihood of severe courses of hepatitis A in MSM. Vaccination against HAV should be recommended for risk groups.</jats:p>