Beschreibung:
<jats:title>Abstract</jats:title>
<jats:p>Inflammation plays a crucial role in the pathogenesis of type 2 diabetes and various lines of evidences suggest an important contribution of type 2 receptor for TNF<jats:italic>α</jats:italic> (TNFR2), a mediator of inflammatory responses. Though genetic association of <jats:italic>TNFRSF1B</jats:italic> (encoding TNFR2) polymorphisms have been investigated in various studies, their involvement is not clear because of inconsistent findings. Because of high susceptibility of Indian population to type 2 diabetes and its complications, we evaluated the association of <jats:italic>TNFRSF1B</jats:italic> polymorphisms-rs1061622 (M196R; exon6) and rs3397 (3′UTR) and (CA)<jats:sub>
<jats:italic>n</jats:italic>
</jats:sub> repeat (intron 4) in 1,852 subjects including 1,040 cases and 812 controls with type 2 diabetes and its associated peripheral neuropathy and hypertension in North Indians of Indo-European ethnicity. The allelic and genotypic distributions of these polymorphisms were comparable among healthy control vs. type 2 diabetes, peripheral neuropathy vs. non-neuropathy and hypertensive vs. normotensive groups. (CA)<jats:sub>
<jats:italic>n</jats:italic>
</jats:sub> polymorphism has been shown to be associated with diabetic neuropathy in Caucasians, however, this could not be replicated in our study (<jats:italic>P</jats:italic> = 0.27). None of the polymorphisms were found to influence the 14 anthropometric and biochemical traits related to type 2 diabetes studied here. Thus, we conclude that <jats:italic>TNFRSF1B</jats:italic> is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians.</jats:p>