> Detailanzeige

Lenti, Marco Vincenzo; Borrelli de Andreis, Federica; Pellegrino, Ivan; Klersy, Catherine; Merli, Stefania; Miceli, Emanuela; Aronico, Nicola; Mengoli, Caterina; Di Stefano, Michele; Cococcia, Sara; Santacroce, Giovanni; Soriano, Simone; Melazzini, Federica; Delliponti, Mariangela; Baldanti, Fausto; Triarico, Antonio; Corazza, Gino Roberto; Pinzani, Massimo; Di Sabatino, Antonio; Bergamaschi, Gaetano; Bertolino, Giampiera; Codega, Silvia; Costanzo, Filippo; Cresci, Roberto; [...]

Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy
  • Beteiligte: Lenti, Marco Vincenzo; Borrelli de Andreis, Federica; Pellegrino, Ivan; Klersy, Catherine; Merli, Stefania; Miceli, Emanuela; Aronico, Nicola; Mengoli, Caterina; Di Stefano, Michele; Cococcia, Sara; Santacroce, Giovanni; Soriano, Simone; Melazzini, Federica; Delliponti, Mariangela; Baldanti, Fausto; Triarico, Antonio; Corazza, Gino Roberto; Pinzani, Massimo; Di Sabatino, Antonio; Bergamaschi, Gaetano; Bertolino, Giampiera; Codega, Silvia; Costanzo, Filippo; Cresci, Roberto; [...]
  • Erschienen: Springer Science and Business Media LLC, 2020
  • Erschienen in: Internal and Emergency Medicine
  • Sprache: Englisch
  • DOI: 10.1007/s11739-020-02425-w
  • ISSN: 1970-9366; 1828-0447
  • Schlagwörter: Emergency Medicine ; Internal Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25–97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was &gt; 50 mU/ml, gamma-glutamyl transpeptidase (GGT) &gt; 50 mU/ml, or total bilirubin &gt; 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO<jats:sub>2</jats:sub>/FiO<jats:sub>2</jats:sub> &lt; 200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07–5.11,<jats:italic>p</jats:italic> = 0.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome.</jats:p>