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Salvio, Andreza Lemos; Fernandes, Renan Amphilophio; Ferreira, Helena França Alcaraz; Duarte, Larissa Araujo; Gutman, Elisa Gouvea; Raposo-Vedovi, Jessica Vasques; Filho, Carlos Henrique Ferreira Ramos; da Costa Nunes Pimentel Coelho, Wagner Luis; Passos, Giselle Fazzioni; Andraus, Maria Emília Cosenza; da Costa Gonçalves, João Paulo; Cavalcanti, Marta Guimarães; Amaro, Marisa Pimentel; Kader, Rafael; de Andrade Medronho, Roberto; Figueiredo, Cláudia Pinto; Amado-Leon, Luciane Almeida; Alves-Leon, Soniza Vieira

High Levels of NfL, GFAP, TAU, and UCH-L1 as Potential Predictor Biomarkers of Severity and Lethality in Acute COVID-19

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  • Medientyp: E-Artikel
  • Titel: High Levels of NfL, GFAP, TAU, and UCH-L1 as Potential Predictor Biomarkers of Severity and Lethality in Acute COVID-19
  • Beteiligte: Salvio, Andreza Lemos; Fernandes, Renan Amphilophio; Ferreira, Helena França Alcaraz; Duarte, Larissa Araujo; Gutman, Elisa Gouvea; Raposo-Vedovi, Jessica Vasques; Filho, Carlos Henrique Ferreira Ramos; da Costa Nunes Pimentel Coelho, Wagner Luis; Passos, Giselle Fazzioni; Andraus, Maria Emília Cosenza; da Costa Gonçalves, João Paulo; Cavalcanti, Marta Guimarães; Amaro, Marisa Pimentel; Kader, Rafael; de Andrade Medronho, Roberto; Figueiredo, Cláudia Pinto; Amado-Leon, Luciane Almeida; Alves-Leon, Soniza Vieira
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Molecular Neurobiology
  • Sprache: Englisch
  • DOI: 10.1007/s12035-023-03803-z
  • ISSN: 0893-7648; 1559-1182
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Few studies showed that neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tubulin-associated unit (TAU), and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) may be related to neurological manifestations and severity during and after SARS-CoV-2 infection. The objective of this work was to investigate the relationship among nervous system biomarkers (NfL, TAU, GFAP, and UCH-L1), biochemical parameters, and viral loads with heterogeneous outcomes in a cohort of severe COVID-19 patients admitted in Intensive Care Unit (ICU) of a university hospital. For that, 108 subjects were recruited within the first 5 days at ICU. In parallel, 16 mild COVID-19 patients were enrolled. Severe COVID-19 group was divided between “deceased” and “survivor.” All subjects were positive for SARS-CoV-2 detection. NfL, total TAU, GFAP, and UCH-L1 quantification in plasma was performed using SIMOA SR-X platform. Of 108 severe patients, 36 (33.33%) presented neurological manifestation and 41 (37.96%) died. All four biomarkers — GFAP, NfL, TAU, and UCH-L1 — were significantly higher among deceased patients in comparison to survivors (<jats:italic>p</jats:italic> &lt; 0.05). Analyzing biochemical biomarkers, higher Peak Serum Ferritin, D-Dimer Peak, Gamma-glutamyltransferase, and C-Reactive Protein levels were related to death (<jats:italic>p</jats:italic> &lt; 0.0001). In multivariate analysis, GFAP, NfL, TAU, UCH-L1, and Peak Serum Ferritin levels were correlated to death. Regarding SARS-CoV-2 viral load, no statistical difference was observed for any group. Thus, Ferritin, NFL, GFAP, TAU, and UCH-L1 are early biomarkers of severity and lethality of SARS-COV-2 infection and may be important tools for therapeutic decision-making in the acute phase of disease.</jats:p>