> Detailanzeige

Mertinkus, Klara R.; Grün, J. Tassilo; Altincekic, Nadide; Bains, Jasleen Kaur; Ceylan, Betül; Ferner, Jan-Peter; Frydman, Lucio; Fürtig, Boris; Hengesbach, Martin; Hohmann, Katharina F.; Hymon, Daniel; Kim, Jihyun; Knezic, Božana; Novakovic, Mihajlo; Oxenfarth, Andreas; Peter, Stephen A.; Qureshi, Nusrat S.; Richter, Christian; Scherf, Tali; Schlundt, Andreas; Schnieders, Robbin; Schwalbe, Harald; Stirnal, Elke; Sudakov, Alexey; [...]

1H, 13C and 15N chemical shift assignment of the stem-loops 5b + c from the 5′-UTR of SARS-CoV-2

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: 1H, 13C and 15N chemical shift assignment of the stem-loops 5b + c from the 5′-UTR of SARS-CoV-2
  • Beteiligte: Mertinkus, Klara R.; Grün, J. Tassilo; Altincekic, Nadide; Bains, Jasleen Kaur; Ceylan, Betül; Ferner, Jan-Peter; Frydman, Lucio; Fürtig, Boris; Hengesbach, Martin; Hohmann, Katharina F.; Hymon, Daniel; Kim, Jihyun; Knezic, Božana; Novakovic, Mihajlo; Oxenfarth, Andreas; Peter, Stephen A.; Qureshi, Nusrat S.; Richter, Christian; Scherf, Tali; Schlundt, Andreas; Schnieders, Robbin; Schwalbe, Harald; Stirnal, Elke; Sudakov, Alexey; [...]
  • Erschienen: Springer Science and Business Media LLC, 2022
  • Erschienen in: Biomolecular NMR Assignments
  • Sprache: Englisch
  • DOI: 10.1007/s12104-021-10053-4
  • ISSN: 1874-2718; 1874-270X
  • Schlagwörter: Biochemistry ; Structural Biology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The ongoing pandemic of the respiratory disease COVID-19 is caused by the SARS-CoV-2 (SCoV2) virus. SCoV2 is a member of the Betacoronavirus genus. The 30 kb positive sense, single stranded RNA genome of SCoV2 features 5′- and 3′-genomic ends that are highly conserved among Betacoronaviruses. These genomic ends contain structured <jats:italic>cis</jats:italic>-acting RNA elements, which are involved in the regulation of viral replication and translation. Structural information about these potential antiviral drug targets supports the development of novel classes of therapeutics against COVID-19. The highly conserved branched stem-loop 5 (SL5) found within the 5′-untranslated region (5′-UTR) consists of a basal stem and three stem-loops, namely SL5a, SL5b and SL5c. Both, SL5a and SL5b feature a 5′-UUUCGU-3′ hexaloop that is also found among Alphacoronaviruses. Here, we report the extensive <jats:sup>1</jats:sup>H, <jats:sup>13</jats:sup>C and <jats:sup>15</jats:sup>N resonance assignment of the 37 nucleotides (nts) long sequence spanning SL5b and SL5c (SL5b + c), as basis for further in-depth structural studies by solution NMR spectroscopy.</jats:p>